MR imaging of a 31-year-old man with bacterial meningo-encephalitis associated with infectious endocarditis demonstrated T2 prolongation and restricted diffusion involving the entire corpus callosum and symmetrically involving the cerebral hemispheric white matter. His neurological signs and symptoms were mild, and recovery was complete within a week. Follow-up MR imaging with a 9-day interval revealed complete resolution of these lesions. The clinical and radiological courses were identical to those previously reported with a reversible lesion isolated to the splenium, or to the splenium and peripheral fronto-parietal white matter. This suggests that such reversible lesions are not necessarily restricted to the splenium, but may involve the entire corpus callosum.