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Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1. 2006
Baogen Wu, and
Kelli Kuhen, and
Truc Ngoc Nguyen, and
David Ellis, and
Beth Anaclerio, and
Xiaohui He, and
Kunyong Yang, and
Donald Karanewsky, and
Hong Yin, and
Karen Wolff, and
Kimberly Bieza, and
Jeremy Caldwell, and
Yun He
Genomics Institute of the Novartis Research Foundation, GNF, 10675 John Jay Hopkins Dr. San Diego, CA 92121, USA. bwu@gnf.org
The synthesis and preliminary structure-activity relationship of a series of pyrrolidinones are described. These pyrrolidinones have been characterized as novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) which are highly potent against wild-type and drug-resistant human immunodeficiency viruses (HIV-1).
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