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A case of systemic lupus erythematosus complicated by pure red cell aplasia and idiopathic portal hypertension after thymectomy. 2006
Haruyo Iwadate, and
Hiroko Kobayashi, and
Kiori Shio, and
Etsuko Noguchi, and
Kenya Watanabe, and
Tomomi Sasajima, and
Hideharu Sekine, and
Hiroshi Watanabe, and
Hiromasa Ohira, and
Katsutoshi Obara, and
Yukio Sato
Department of Internal Medicine II, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. haru-i@fmu.ac.jp
We describe a 49-year-old woman who presented in 2002 with pure red cell aplasia (PRCA), systemic lupus erythematosus (SLE), and idiopathic portal hypertension (IPH) that developed following a thymectomy. She underwent a thymectomy at 40 years of age to treat myasthenia gravis. PRCA developed 3 years after the thymectomy and she was successfully treated with cyclosporin. Systemic lupus erythematosus and IPH were diagnosed 6 years later. We conclude that immunological dysfunction resulting from the thymectomy contributed significantly to the subsequent development of PRCA, SLE, and IPH in this patient. This is the first report to describe this extremely rare occurrence.
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