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A novel method to convert triptolide into tripchlorolide in Tripterygium wilfordii. 2006

Baozhi Li, and Jie Bai, and Gengliang Yang, and Zhiwei Li, and Lijuan Wang, and Yi Chen
College of Pharmacy, Hebei University, Baoding 071002, People's Republic of China.

A new method has been established to convert triptolide (1) into tripchlorolide (2) directly in the Chinese herbal drug Tripterygium wilfordii Hook F. and the influences of reaction times and pH values have been investigated. It was found that 1 could be most efficiently converted into 2 using a hydrochloric acid-acetic acid system. An HPLC method was devised in order to monitor the conversion and ESI-MS was used to identify the synthetic product 2. The sensitivity of the assay was sufficient to monitor the conversion of the main active components in T. wilfordii.

UI MeSH Term Description Entries
D010616 Phenanthrenes POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.
D004224 Diterpenes Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate. Diterpene,Diterpenes, Cembrane,Diterpenes, Labdane,Diterpenoid,Labdane Diterpene,Norditerpene,Norditerpenes,Norditerpenoid,Cembranes,Diterpenoids,Labdanes,Norditerpenoids,Cembrane Diterpenes,Diterpene, Labdane,Labdane Diterpenes
D004852 Epoxy Compounds Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS. Epoxide,Epoxides,Epoxy Compound,Oxiranes,Compound, Epoxy,Compounds, Epoxy
D006863 Hydrogen-Ion Concentration The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D018517 Plant Roots The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990) Plant Bulbs,Plant Root,Bulb, Plant,Bulbs, Plant,Plant Bulb,Root, Plant,Roots, Plant
D029757 Tripterygium A plant genus of the family CELASTRACEAE that is a source of triterpenoids and diterpene epoxides such as triptolide. Tripterygium wilfordii,Leigong Teng,Thundergod Vine,Tripterygium hypoglaucum,Leigong Tengs,Teng, Leigong,Tengs, Leigong,Thundergod Vines,Tripterygium hypoglaucums,Tripterygium wilfordius,Tripterygiums,Vine, Thundergod,Vines, Thundergod,hypoglaucums, Tripterygium,wilfordius, Tripterygium

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