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The uptake of 131-I in chicken ova was studied for 3 hours after a single intramuscular dose. There was uptake as early as 10 minutes and it continued throughout the 3 hours in spite of a rapid decrease in blood activity. The fast growing ova, weightin 0.5 to 2.0 grams, were the most efficient in the uptake of 131-I per unit weight. Autoradiograms of the topographic distribution of 131-I showed a peripheral deposition. When multiple doses were given, concentric rings in the growing ovocytes were seen.
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