Protocadherin-PC promotes androgen-independent prostate cancer cell growth. 2006

Stephane Terry, and Luis Queires, and Sixtina Gil-Diez-de-Medina, and Min-Wei Chen, and Alexandre de la Taille, and Yves Allory, and Phuong-Lan Tran, and Claude C Abbou, and Ralph Buttyan, and Francis Vacherot
Department of Urology and Pathology of CHU Henri Mondor, INSERM E 03-37, Université Paris XII, Centre de Recherches Chirurgicales, Assistance Publique des Hôpitaux de Paris, Créteil, France.

BACKGROUND Protocadherin-PC (PCDH-PC) expression is upregulated in apoptosis-resistant sublines of the LNCaP human prostate cancer (CaP) cell line. Here, we assess the role of PCDH-PC in CaP cells and its mRNA expression in human prostate tissues. METHODS LNCaP cells transfected with PCDH-PC were tested for their ability to grow in vitro and in vivo in androgen-deprived conditions. PCDH-PC mRNA expression was evaluated by semi-quantitative RT-PCR and by in situ hybridization. RESULTS PCDH-PC expression induced Wnt signaling in CaP cells and permitted androgen-independent growth of hormone-sensitive CaP cells. Expression of PCDH-PC-homologous transcripts was low and restricted to some epithelial cells in normal tissue and to CaP cells in tumors. However, hormone-resistant CaP cells expressed significantly higher levels of PCDH-PC-related mRNA. CONCLUSIONS Our findings suggest a novel mechanism for the progression of CaP involving expression of PCDH-PC. This novel protocadherin induces Wnt signaling, promotes malignant behavior and hormone-resistance of CaP cells.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008297 Male Males
D008819 Mice, Nude Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses. Athymic Mice,Mice, Athymic,Nude Mice,Mouse, Athymic,Mouse, Nude,Athymic Mouse,Nude Mouse
D009376 Neoplasms, Hormone-Dependent Certain tumors that 1, arise in organs that are normally dependent on specific hormones and 2, are stimulated or caused to regress by manipulation of the endocrine environment. Hormone-Dependent Neoplasms,Hormone Dependent Neoplasms,Hormone-Dependent Neoplasm,Neoplasm, Hormone-Dependent,Neoplasms, Hormone Dependent
D011467 Prostate A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM. Prostates
D011471 Prostatic Neoplasms Tumors or cancer of the PROSTATE. Cancer of Prostate,Prostate Cancer,Cancer of the Prostate,Neoplasms, Prostate,Neoplasms, Prostatic,Prostate Neoplasms,Prostatic Cancer,Cancer, Prostate,Cancer, Prostatic,Cancers, Prostate,Cancers, Prostatic,Neoplasm, Prostate,Neoplasm, Prostatic,Prostate Cancers,Prostate Neoplasm,Prostatic Cancers,Prostatic Neoplasm
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000091363 Protocadherins Members of cadherin superfamily involved in cell adhesion and cell-cell interactions in neural development. They are subdivided into clustered (cPcdhs) and non-clustered protocadherin (ncPcdhs) depending whether their genes are tandemly arranged in vertebrates. Cadherin-Related Neuronal Receptors,Clustered Pcdhs,Clustered Protocadherins,Non-Clustered Pcdhs,Non-Clustered Protocadherins,cPcdhs,ncPcdhs,Cadherin Related Neuronal Receptors,Neuronal Receptors, Cadherin-Related,Non Clustered Pcdhs,Non Clustered Protocadherins,Pcdhs, Clustered,Pcdhs, Non-Clustered,Protocadherins, Clustered,Protocadherins, Non-Clustered,Receptors, Cadherin-Related Neuronal
D000728 Androgens Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power. Androgen,Androgen Receptor Agonist,Androgen Effect,Androgen Effects,Androgen Receptor Agonists,Androgenic Agents,Androgenic Compounds,Agents, Androgenic,Agonist, Androgen Receptor,Agonists, Androgen Receptor,Compounds, Androgenic,Effect, Androgen,Effects, Androgen,Receptor Agonist, Androgen,Receptor Agonists, Androgen
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

Stephane Terry, and Luis Queires, and Sixtina Gil-Diez-de-Medina, and Min-Wei Chen, and Alexandre de la Taille, and Yves Allory, and Phuong-Lan Tran, and Claude C Abbou, and Ralph Buttyan, and Francis Vacherot
July 2016, Oncotarget,
Stephane Terry, and Luis Queires, and Sixtina Gil-Diez-de-Medina, and Min-Wei Chen, and Alexandre de la Taille, and Yves Allory, and Phuong-Lan Tran, and Claude C Abbou, and Ralph Buttyan, and Francis Vacherot
September 2013, Cancer research,
Stephane Terry, and Luis Queires, and Sixtina Gil-Diez-de-Medina, and Min-Wei Chen, and Alexandre de la Taille, and Yves Allory, and Phuong-Lan Tran, and Claude C Abbou, and Ralph Buttyan, and Francis Vacherot
December 2003, The Journal of clinical investigation,
Stephane Terry, and Luis Queires, and Sixtina Gil-Diez-de-Medina, and Min-Wei Chen, and Alexandre de la Taille, and Yves Allory, and Phuong-Lan Tran, and Claude C Abbou, and Ralph Buttyan, and Francis Vacherot
March 2005, Archives of biochemistry and biophysics,
Stephane Terry, and Luis Queires, and Sixtina Gil-Diez-de-Medina, and Min-Wei Chen, and Alexandre de la Taille, and Yves Allory, and Phuong-Lan Tran, and Claude C Abbou, and Ralph Buttyan, and Francis Vacherot
January 2003, Clinical cancer research : an official journal of the American Association for Cancer Research,
Stephane Terry, and Luis Queires, and Sixtina Gil-Diez-de-Medina, and Min-Wei Chen, and Alexandre de la Taille, and Yves Allory, and Phuong-Lan Tran, and Claude C Abbou, and Ralph Buttyan, and Francis Vacherot
December 2003, BJU international,
Stephane Terry, and Luis Queires, and Sixtina Gil-Diez-de-Medina, and Min-Wei Chen, and Alexandre de la Taille, and Yves Allory, and Phuong-Lan Tran, and Claude C Abbou, and Ralph Buttyan, and Francis Vacherot
April 2012, International journal of cancer,
Stephane Terry, and Luis Queires, and Sixtina Gil-Diez-de-Medina, and Min-Wei Chen, and Alexandre de la Taille, and Yves Allory, and Phuong-Lan Tran, and Claude C Abbou, and Ralph Buttyan, and Francis Vacherot
January 2011, PloS one,
Stephane Terry, and Luis Queires, and Sixtina Gil-Diez-de-Medina, and Min-Wei Chen, and Alexandre de la Taille, and Yves Allory, and Phuong-Lan Tran, and Claude C Abbou, and Ralph Buttyan, and Francis Vacherot
June 2006, Oncogene,
Stephane Terry, and Luis Queires, and Sixtina Gil-Diez-de-Medina, and Min-Wei Chen, and Alexandre de la Taille, and Yves Allory, and Phuong-Lan Tran, and Claude C Abbou, and Ralph Buttyan, and Francis Vacherot
February 2008, Zhonghua nan ke xue = National journal of andrology,
Copied contents to your clipboard!