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A peptide acidic hydrolysate of collagen (PHC) was obtained under conditions (4 N HCl) ensuring the predominant formation of short peptides, glyprolines. They were separated and their antiulcer activity was studied. Thirty individual peptides with molecular masses of 174-420 amu were isolated from the PHC by HPLC. The PHC was shown to predominantly contain 2- to 4-aa peptides, including PG, GP, and PGP. Experiments on rats demonstrated that, on intragastric administration at a dose of 1 mg/kg, PHC enhances the stability of the gastric mucosa to the action of ulcerogenic factors, such as ethanol and stress, and exhibits a protecting antiulcer effect. Even a lesser dose (0.1 mg/kg), which reduced ulcer area twofold, was effective in the stress model of ulcer formation. The intraperitoneal and intragastric administration of PHC at a dose of 1 mg/kg was found to exhibit a therapeutic effect in the acetate model of ulcer formation.
Iu A Zolotarev, and
K E Badmaeva, and
Z V Bakaeva, and
G E Samonina, and
G N Kopylova, and
A K Dadaian, and
Iu B Zverkov, and
S K Garanin, and
B V Vas'kovskiĭ, and
I P Ashmarin, and
N F Miasoedov
September 1998,
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
Iu A Zolotarev, and
K E Badmaeva, and
Z V Bakaeva, and
G E Samonina, and
G N Kopylova, and
A K Dadaian, and
Iu B Zverkov, and
S K Garanin, and
B V Vas'kovskiĭ, and
I P Ashmarin, and
N F Miasoedov
February 2024,
Macromolecular rapid communications,
Iu A Zolotarev, and
K E Badmaeva, and
Z V Bakaeva, and
G E Samonina, and
G N Kopylova, and
A K Dadaian, and
Iu B Zverkov, and
S K Garanin, and
B V Vas'kovskiĭ, and
I P Ashmarin, and
N F Miasoedov
December 1985,
Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan,
Iu A Zolotarev, and
K E Badmaeva, and
Z V Bakaeva, and
G E Samonina, and
G N Kopylova, and
A K Dadaian, and
Iu B Zverkov, and
S K Garanin, and
B V Vas'kovskiĭ, and
I P Ashmarin, and
N F Miasoedov
June 2023,
Food chemistry,
Iu A Zolotarev, and
K E Badmaeva, and
Z V Bakaeva, and
G E Samonina, and
G N Kopylova, and
A K Dadaian, and
Iu B Zverkov, and
S K Garanin, and
B V Vas'kovskiĭ, and
I P Ashmarin, and
N F Miasoedov
January 1971,
FEBS letters,
Iu A Zolotarev, and
K E Badmaeva, and
Z V Bakaeva, and
G E Samonina, and
G N Kopylova, and
A K Dadaian, and
Iu B Zverkov, and
S K Garanin, and
B V Vas'kovskiĭ, and
I P Ashmarin, and
N F Miasoedov
August 2010,
Journal of the science of food and agriculture,
Iu A Zolotarev, and
K E Badmaeva, and
Z V Bakaeva, and
G E Samonina, and
G N Kopylova, and
A K Dadaian, and
Iu B Zverkov, and
S K Garanin, and
B V Vas'kovskiĭ, and
I P Ashmarin, and
N F Miasoedov
January 2009,
Angewandte Chemie (International ed. in English),
Iu A Zolotarev, and
K E Badmaeva, and
Z V Bakaeva, and
G E Samonina, and
G N Kopylova, and
A K Dadaian, and
Iu B Zverkov, and
S K Garanin, and
B V Vas'kovskiĭ, and
I P Ashmarin, and
N F Miasoedov
March 2023,
Food chemistry,
Iu A Zolotarev, and
K E Badmaeva, and
Z V Bakaeva, and
G E Samonina, and
G N Kopylova, and
A K Dadaian, and
Iu B Zverkov, and
S K Garanin, and
B V Vas'kovskiĭ, and
I P Ashmarin, and
N F Miasoedov
December 2023,
Antibiotics (Basel, Switzerland),
Iu A Zolotarev, and
K E Badmaeva, and
Z V Bakaeva, and
G E Samonina, and
G N Kopylova, and
A K Dadaian, and
Iu B Zverkov, and
S K Garanin, and
B V Vas'kovskiĭ, and
I P Ashmarin, and
N F Miasoedov
March 2022,
Antioxidants (Basel, Switzerland),
