The surgery of metastatic gastrointestinal malignancies comes into prominence nowadays. Positive observations inspire the increase of surgical radicality. Occurrence of peritoneal carcinosis means a very bad prognosis. However, on the base of the literature and our experiences the prognosis can be improved in some well-defined groups of patients. We present the method and opportunity of using peritonectomy and intraperitoneal chemotherapy in connection with two cases. We review the method developed and improved by Sugarbaker and his workgroup. Good results can be achieved by this combined technique in the cases of less invasive tumours, for example pseudomyxoma peritonei and peritoneal mesothelioma. Good result can also be achieved in the cases of more aggressive tumours if they are in resectable stage with not so extensive peritoneal seeding. Surveying the literature we can find encouraging results concerning ovarian cancer, gastric and colo-rectal cancer accompanied by peritoneal seeding.