Biomaterial Database

[Pharmacokinetics of sodium selenite in human body at different levels of selenium]. 1991

J A Guo, and X Y Wang, and L M Dai

Institute of Basic Medical Sciences of Liaoning Province, Shenyang, China.

Twelve health adults (6 M, 6 F) from the endemic area of Keshan disease and Kaschin-Beck's disease and 12 adults from nonaffected area were administered a single oral dose of 4 mg sodium selenite. Selenium in whole blood was determined by fluorescence spectrometry. Their basic levels of blood selenium were 64 +/- 16 and 220 +/- 20 ng.ml-1, respectively. The concentration-time data were treated by a computer with program 3P87, which revealed 2-compartment models with first order absorption and lag time. The pharmacokinetic parameters of low-Se group were T1/2g 1.8 +/- 0.6h, T1/2g 72 +/- 18 h, T1/2ka 3.2 +/- 1.8h, AUC 3,100 +/- 500 ng.h.ml-1, CL 32 +/- 7 ml.kg-1.h-1, Vc 1.45 +/- 0.19 L.kg-1, Tp 6.1 +/- 2.0 h, Cp 36 +/- 4 ng.ml-1, AUMC (S1) 130 +/- 26, VRT 174 +/- 17 h, MRT 55 +/- 4 h, and of normal-Se group were T1/2 3.4 +/- 0.7h, T1/2g 14 +/- 3 h. T1/2ka 2.3 +/- 0.6, AUC 1,420 +/- 210 ng.h.ml-1, Cl 57 +/- 7 ml.kg-1. h-1, Vc 0.54 +/- 0.09 L.kg-1, Tp 4.6 +/- 0.9h, Cp 75 +/- 5 ng.ml-1, AUMC (S1) 25 +/- 5, VRT 16 +/- 3 h, MRT 16.1 +/- 1.5 h.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009202	Cardiomyopathies	A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).	Myocardial Disease,Myocardial Diseases,Myocardial Diseases, Primary,Myocardial Diseases, Secondary,Myocardiopathies,Primary Myocardial Disease,Cardiomyopathies, Primary,Cardiomyopathies, Secondary,Primary Myocardial Diseases,Secondary Myocardial Diseases,Cardiomyopathy,Cardiomyopathy, Primary,Cardiomyopathy, Secondary,Disease, Myocardial,Disease, Primary Myocardial,Disease, Secondary Myocardial,Diseases, Myocardial,Diseases, Primary Myocardial,Diseases, Secondary Myocardial,Myocardial Disease, Primary,Myocardial Disease, Secondary,Myocardiopathy,Primary Cardiomyopathies,Primary Cardiomyopathy,Secondary Cardiomyopathies,Secondary Cardiomyopathy,Secondary Myocardial Disease
D010003	Osteoarthritis	A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.	Arthritis, Degenerative,Osteoarthrosis,Osteoarthrosis Deformans,Arthroses,Arthrosis,Arthritides, Degenerative,Degenerative Arthritides,Degenerative Arthritis,Osteoarthritides,Osteoarthroses
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012643	Selenium	An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.	Selenium-80,Selenium 80
D013050	Spectrometry, Fluorescence	Measurement of the intensity and quality of fluorescence.	Fluorescence Spectrophotometry,Fluorescence Spectroscopy,Spectrofluorometry,Fluorescence Spectrometry,Spectrophotometry, Fluorescence,Spectroscopy, Fluorescence
D018038	Sodium Selenite	The disodium salt of selenious acid. It is used therapeutically to supply the trace element selenium and is prepared by the reaction of SELENIUM DIOXIDE with SODIUM HYDROXIDE.	Disodium Selenite,Monosodium Selenite,Selenous Acid Disodium Salt,Selenous Acid, Disodium Salt,Sodium Biselenite,Sodium Selenite Pentahydrate,Biselenite, Sodium,Pentahydrate, Sodium Selenite,Selenite Pentahydrate, Sodium,Selenite, Disodium,Selenite, Monosodium,Selenite, Sodium