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(1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) and (1R,3S)-1-aminocyclopentane-1,3-dicarboxylic acid (1R,3S-ACPD) were characterized for potency, efficacy, and selectivity at metabotropic excitatory amino acid receptors. 1S,3R-ACPD stimulated [3H]phosphoinositide hydrolysis in slices of the neonatal and adult rat hippocampus with full efficacy and twice the potency relative to what has been shown for (+/-)-trans-ACPD. 1S,3R-ACPD was up to 30 times more potent in activating metabotropic excitatory amino acid receptors, compared to its affinity for [3H]CGS19755 binding to NMDA receptors. In contrast, 1R,3S-ACPD was much less potent, efficacious, and selective than 1S,3R-ACPD. Although 1S,3R-ACPD is not specific, it is a most selective and efficacious agonist at metabotropic excitatory amino acid receptors.
D D Schoepp, and
B G Johnson, and
R A True, and
J A Monn
November 2001,
Journal of neurochemistry,
D D Schoepp, and
B G Johnson, and
R A True, and
J A Monn
January 1994,
Neuropharmacology,
D D Schoepp, and
B G Johnson, and
R A True, and
J A Monn
November 2002,
The Journal of organic chemistry,
D D Schoepp, and
B G Johnson, and
R A True, and
J A Monn
August 1995,
Neuropharmacology,
D D Schoepp, and
B G Johnson, and
R A True, and
J A Monn
June 1994,
The Journal of general physiology,
D D Schoepp, and
B G Johnson, and
R A True, and
J A Monn
January 1995,
Polish journal of pharmacology,
D D Schoepp, and
B G Johnson, and
R A True, and
J A Monn
April 2002,
Bioscience, biotechnology, and biochemistry,
D D Schoepp, and
B G Johnson, and
R A True, and
J A Monn
July 1994,
Journal of neurochemistry,
D D Schoepp, and
B G Johnson, and
R A True, and
J A Monn
August 1993,
European journal of pharmacology,
D D Schoepp, and
B G Johnson, and
R A True, and
J A Monn
February 1996,
Brain research,
