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The administration of a single, 100-300 mg/kg ip, dose of a B6 vitamer to rats resulted in an almost immediate and gradual mobilization of the liver glycogen and a concomitant elevation of the serum glucose, with the order of potency being pyridoxal greater than pyridoxamine greater than pyridoxine. Since the B6 vitamer also stimulated the secretion of adrenal catecholamines and the accumulation of liver cAMP, and a pretreatment with selected blocking agents conferred significant protection against the glycogen depletion in the order of potency propranolol + phentolamine greater than propranolol greater than verapamil greater than phentolamine, a role for an adrenomedullary catecholamine-stimulated, beta-adrenoceptor-mediated, activation of the glycogen cascade system was suggested. This assumption was confirmed by verifying pyridoxal to possess virtually no effect on the liver glycogen of adrenalectomized rats.
C A Lau-Cam, and
K P Thadikonda, and
B F Kendall
April 1986,
Indian journal of experimental biology,
C A Lau-Cam, and
K P Thadikonda, and
B F Kendall
August 1986,
The Biochemical journal,
C A Lau-Cam, and
K P Thadikonda, and
B F Kendall
September 1978,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
C A Lau-Cam, and
K P Thadikonda, and
B F Kendall
October 1985,
The Indian journal of medical research,
C A Lau-Cam, and
K P Thadikonda, and
B F Kendall
June 1981,
The Journal of biological chemistry,
C A Lau-Cam, and
K P Thadikonda, and
B F Kendall
January 1990,
Annals of the New York Academy of Sciences,
C A Lau-Cam, and
K P Thadikonda, and
B F Kendall
January 1983,
Annals of nutrition & metabolism,
C A Lau-Cam, and
K P Thadikonda, and
B F Kendall
August 1971,
Canadian journal of biochemistry,
C A Lau-Cam, and
K P Thadikonda, and
B F Kendall
February 1958,
Casopis lekaru ceskych,
C A Lau-Cam, and
K P Thadikonda, and
B F Kendall
June 1970,
The Journal of pharmacy and pharmacology,
