[Severe drug hepatitis caused by Chelidonium]. 2006

K Rifai, and P Flemming, and M P Manns, and C Trautwein
Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625, Hannover. rifai.k@gmx.de

We report the case of a 58-year-old male patient who was admitted with severe acute cholestatic hepatitis. Liver biopsy showed signs of drug-induced hepatitis. Other causes of acute hepatitis were excluded. Therefore, the ingestion of a Chelidonium-containing preparation (celandine) was thought to be responsible for the hepatitis. Shortly after stopping the administration of Chelidonium, the highly pathological levels of several liver parameters began to normalise. As no autoantibodies were detectable, an idiosyncratic reaction as the cause of drug-induced hepatitis is probable. In cases of unknown hepatitis, herbal medications should be taken into account as a possible cause.

UI MeSH Term Description Entries
D008297 Male Males
D008517 Phytotherapy Use of plants or herbs to treat diseases or to alleviate pain. Herb Therapy,Herbal Therapy
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D056487 Chemical and Drug Induced Liver Injury, Chronic Liver disease lasting six months or more, caused by an adverse effect of a drug or chemical. The adverse effect may be caused by drugs, drug metabolites, chemicals from the environment, or an idiosyncratic response. Chronic Drug-Induced Liver Injury,Drug-Induced Liver Injury, Chronic,Liver Injury, Drug-Induced, Chronic,Chemical-Induced Liver Injury, Chronic,Chemically-Induced Liver Injury, Chronic,Hepatitis, Chronic, Drug-Induced,Hepatitis, Chronic, Drug-Related,Chemical Induced Liver Injury, Chronic,Chemically Induced Liver Injury, Chronic,Chronic Drug Induced Liver Injury,Drug Induced Liver Injury, Chronic
D028281 Chelidonium A plant genus in the family PAPAVERACEAE, order Papaverales, subclass Magnoliidae. Celandine,Celandines,Chelidoniums

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