The random clustering of amorphous calcium phosphate (ACP) particles within resin matrices is thought to diminish the strength of their polymerized composites. The objective of this study was to elucidate the effect of ball-milling on the particle size distribution (PSD) of ACP fillers and assess if improved dispersion of milled ACP in methacrylate resin sufficiently enhanced filler/matrix interactions to result in improved biaxial flexure strength (BFS), without compromising the remineralizing potential of the composites. Unmilled and wet-milled zirconia-hybridized ACP (Zr-ACP) fillers were characterized by PSD analysis, X-ray diffraction, thermogravimetric and chemical analysis, infrared spectroscopy, and scanning electron microscopy. Composite specimens made from a photoactivated, ternary methacrylate resin admixed with a mass fraction of 40% of un-milled or milled Zr-ACP were evaluated for the BFS (dry and wet) and for the release of calcium and phosphate ions into saline solutions. While having no apparent effect on the structure, composition, and morphology/topology of the fillers, milling significantly reduced the average size of Zr-ACP particulates (median diameter, d(m) = 0.9 +/- 0.2 microm) and the spread of their PSD. Better dispersion of milled Zr-ACP in the resins resulted in the improved BFS of the composites, even after aqueous soaking, and also gave a satisfactory ion release profile. The demonstrated improvement in the mechanical stability of anti-demineralizing/remineralizing ACP composites based on milled Zr-ACP filler may be beneficial in potentially extending their dental utility.