-transparent.png){kind=logo}
The central nervous system (CNS) of DBA/2 mice inoculated i.p. with the D variant of encephalomyocarditis virus (EMC-D) (10(3) PFU/head) was examined up to 28 days postinoculation (28 DPI). The virus titer of CNS reached a maximum level at 4 DPI, and infectious viruses became undetectable by 28 DPI. Histopathologically, degeneration of neurons with virus antigens was observed in St. pyramidale hippocampi, Nuc. amigdaloideus corticalis and St. granulosum cerebelli of the brain and in Cornu ventrale of the thoracic to lumbar spinal cord at 6 DPI. In addition, in the spinal cord, demyelination was found in Funiculus ventralis and Funiculus lateralis at 6 DPI and it progressed to form spongiosis at 10 DPI. In correspondence with these virological and histopathological findings, hind limb paralysis developed in some mice at 6 DPI, and its incidence increased markedly to about 60% at 10 DPI.
M Takeda, and
K Hirasawa, and
K Doi
October 1993,
International journal of experimental pathology,
M Takeda, and
K Hirasawa, and
K Doi
June 1989,
British journal of experimental pathology,
M Takeda, and
K Hirasawa, and
K Doi
October 1971,
Cardiovascular research,
M Takeda, and
K Hirasawa, and
K Doi
December 1981,
Japanese circulation journal,
M Takeda, and
K Hirasawa, and
K Doi
January 2004,
Experimental animals,
M Takeda, and
K Hirasawa, and
K Doi
August 2004,
Experimental and molecular pathology,
M Takeda, and
K Hirasawa, and
K Doi
June 1971,
Experimental and molecular pathology,
M Takeda, and
K Hirasawa, and
K Doi
June 1988,
British journal of experimental pathology,
M Takeda, and
K Hirasawa, and
K Doi
February 2005,
Experimental and molecular pathology,
M Takeda, and
K Hirasawa, and
K Doi
March 1980,
Diabetologia,
