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We present a case report on a 35-year-old patient in whom a malignant sympathetic paraganglioma of the organ of Zuckerkandl was the cause of severe hypertension with excessive perspiration at night. Since curative surgery was not possible medical treatment was initiated. Interferon alfa 2b (Intron A, Essex Pharma) and the somatostatin-analogue SMS 201-995 (Sandostatin, Sandoz) had no effect on catecholamine production and progression of the tumor. Treatment with alpha-methyl-para-tyrosin (MPT, [Metyrosin], Demser, MSD) turned out to be an effective and well tolerable therapy in this patient with peritoneal carcinosis. Clinical and hormonal progression of the paraganglioma resumed only after two years of therapy, which constitutes the longest documented period of time of successful MPT treatment. The superior efficacy of MPT in our patient should encourage postoperative medical treatment with MPT in malignant pheochromocytoma or malignant paraganglioma, particularly when the tumor turns out to be resistent to alpha blocking drugs.
F Schuppert, and
G F Scheumann, and
C Schöber, and
J Overbeck, and
T H Schürmeyer, and
H J Schmoll, and
H Dralle, and
A von zur Mühlen
October 1956,
A.M.A. archives of pathology,
F Schuppert, and
G F Scheumann, and
C Schöber, and
J Overbeck, and
T H Schürmeyer, and
H J Schmoll, and
H Dralle, and
A von zur Mühlen
October 2002,
Journal des maladies vasculaires,
F Schuppert, and
G F Scheumann, and
C Schöber, and
J Overbeck, and
T H Schürmeyer, and
H J Schmoll, and
H Dralle, and
A von zur Mühlen
January 1952,
A.M.A. archives of pathology,
F Schuppert, and
G F Scheumann, and
C Schöber, and
J Overbeck, and
T H Schürmeyer, and
H J Schmoll, and
H Dralle, and
A von zur Mühlen
April 1978,
Urology,
F Schuppert, and
G F Scheumann, and
C Schöber, and
J Overbeck, and
T H Schürmeyer, and
H J Schmoll, and
H Dralle, and
A von zur Mühlen
November 1968,
Orvosi hetilap,
F Schuppert, and
G F Scheumann, and
C Schöber, and
J Overbeck, and
T H Schürmeyer, and
H J Schmoll, and
H Dralle, and
A von zur Mühlen
June 1954,
Annals of internal medicine,
F Schuppert, and
G F Scheumann, and
C Schöber, and
J Overbeck, and
T H Schürmeyer, and
H J Schmoll, and
H Dralle, and
A von zur Mühlen
January 2012,
The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society,
F Schuppert, and
G F Scheumann, and
C Schöber, and
J Overbeck, and
T H Schürmeyer, and
H J Schmoll, and
H Dralle, and
A von zur Mühlen
January 1994,
Chirurgie; memoires de l'Academie de chirurgie,
F Schuppert, and
G F Scheumann, and
C Schöber, and
J Overbeck, and
T H Schürmeyer, and
H J Schmoll, and
H Dralle, and
A von zur Mühlen
July 1982,
Journal of surgical oncology,
F Schuppert, and
G F Scheumann, and
C Schöber, and
J Overbeck, and
T H Schürmeyer, and
H J Schmoll, and
H Dralle, and
A von zur Mühlen
March 2017,
Oncology letters,
