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The interaction of insulin with its receptors was studied in liver plasma membranes of the young non-obese hereditary diabetic mouse (KK strain). Under identical conditions of preparation and incubation, the membranes of the KK mouse bind only 55-70% as much insulin per mg of protein as those of the control mouse (Swiss albino). Scatchard analysis suggests that this decrease in binding is due to a decrease in the number of receptor sites in the membrane of the diabetic mouse. However, the membranes of diabetic and control mice do not exhibit significant differences in hexosamine and sialic acid contents, enzyme activities, and protein and glycoprotein analysis. The decrease in insulin receptors in the KK mouse seems to correlate with the insulin resistance which they exhibit.
P Kern, and
J Picard, and
M Caron, and
D Veissière
March 1991,
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P Kern, and
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D Veissière
January 1984,
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P Kern, and
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August 1971,
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P Kern, and
J Picard, and
M Caron, and
D Veissière
January 1986,
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P Kern, and
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D Veissière
January 1984,
Comparative biochemistry and physiology. A, Comparative physiology,
P Kern, and
J Picard, and
M Caron, and
D Veissière
October 1984,
The Japanese journal of experimental medicine,
P Kern, and
J Picard, and
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D Veissière
January 1977,
The Journal of clinical endocrinology and metabolism,
P Kern, and
J Picard, and
M Caron, and
D Veissière
December 1974,
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P Kern, and
J Picard, and
M Caron, and
D Veissière
January 1983,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
P Kern, and
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D Veissière
November 1980,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
