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We have studied the effects of intracellular cyclic AMP (cAMP) on the response to N-methyl-D-aspartate (NMDA) in hippocampal cultured neurons by loading them with 2'-o-dibutyryladenosine 3', 5'-cyclic monophosphate (dcAMP) and have obtained evidence for regulation of Ca2+ release from intracellular stores by cAMP. Extracellular Ringer's solution was either Ca(2+)-containing or Ca(2+)-free. A brief initial stimulation with NMDA (10-100 microM, 12 s) was required before the neurons were loaded with dcAMP to potentiate the changes in intracellular Ca2+ concentration induced by the second stimulus of NMDA. Forskolin (10 microM) mimicked dcAMP, but to a lesser extent. A phorbol ester 12-o-tetradecanoylphorbol-13-acetate (100 nM) inhibited the effect of dcAMP.
K Harada, and
Y Nagatsugu, and
H Ito, and
R Shingai
May 2000,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
K Harada, and
Y Nagatsugu, and
H Ito, and
R Shingai
February 1999,
Nature neuroscience,
K Harada, and
Y Nagatsugu, and
H Ito, and
R Shingai
October 1997,
Neuron,
K Harada, and
Y Nagatsugu, and
H Ito, and
R Shingai
February 1993,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
K Harada, and
Y Nagatsugu, and
H Ito, and
R Shingai
January 2019,
Neuroscience,
K Harada, and
Y Nagatsugu, and
H Ito, and
R Shingai
June 2007,
Molecular and cellular neurosciences,
K Harada, and
Y Nagatsugu, and
H Ito, and
R Shingai
October 1995,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
K Harada, and
Y Nagatsugu, and
H Ito, and
R Shingai
August 2013,
Proceedings of the National Academy of Sciences of the United States of America,
K Harada, and
Y Nagatsugu, and
H Ito, and
R Shingai
November 2008,
Neurochemistry international,
K Harada, and
Y Nagatsugu, and
H Ito, and
R Shingai
June 2011,
Neuroscience research,
