BIOMAT Database Logo BIOMAT Database Logo

The macrophage scavenger receptor SR-AI/II and lung defense against pneumococci and particles. 2006

Mohamed S Arredouani, and Zhiping Yang, and Amy Imrich, and Yaoyu Ning, and Guozhong Qin, and Lester Kobzik
Physiology Program, 665 Huntington Avenue, SPH-II, Room 221, Boston, MA 02115, USA.

The class A macrophage scavenger receptor SR-AI/II is implicated as a pattern recognition receptor for innate immunity, but its functional role in lung defense has not been studied. We used mice genetically deficient in SR-AI/II and their wild-type C57BL/6 counterparts to investigate the contribution of this receptor to defense against pneumococcal infection and inhaled particles. SR-AI/II deficiency caused impaired phagocytosis of fluorescent bacteria in vivo, diminished clearance of live bacteria from the lungs, and substantially increased pneumonic inflammation. Survival studies also showed increased mortality in SR-AI/II-deficient mice with pneumococcal lung infection. Similarly, after challenge of the airways with TiO(2) particles, SR-AI/II-deficient mice showed increased proinflammatory cytokine levels in lung lavage fluid and a more pronounced neutrophilic inflammation. The data indicate that the lung macrophage class A scavenger receptor SR-AI/II contributes to innate defense against bacteria and inhaled particles.

UI MeSH Term Description Entries
D007113 Immunity, Innate The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS. Immunity, Native,Immunity, Natural,Immunity, Non-Specific,Resistance, Natural,Innate Immune Response,Innate Immunity,Immune Response, Innate,Immune Responses, Innate,Immunity, Non Specific,Innate Immune Responses,Native Immunity,Natural Immunity,Natural Resistance,Non-Specific Immunity
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008297 Male Males
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D010587 Phagocytosis The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES). Phagocytoses
D011018 Pneumonia, Pneumococcal A febrile disease caused by STREPTOCOCCUS PNEUMONIAE. Pneumococcal Pneumonia,Pneumococcal Pneumonias,Pneumonias, Pneumococcal
D004198 Disease Susceptibility A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases. Diathesis,Susceptibility, Disease,Diatheses,Disease Susceptibilities,Susceptibilities, Disease
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014025 Titanium A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.

Related Publications

Mohamed S Arredouani, and Zhiping Yang, and Amy Imrich, and Yaoyu Ning, and Guozhong Qin, and Lester Kobzik
[Scavenger receptor class A type I/II (SR-AI/II)].
February 2001, Nihon rinsho. Japanese journal of clinical medicine,
Mohamed S Arredouani, and Zhiping Yang, and Amy Imrich, and Yaoyu Ning, and Guozhong Qin, and Lester Kobzik
Direct recognition of superparamagnetic nanocrystals by macrophage scavenger receptor SR-AI.
May 2013, ACS nano,
Mohamed S Arredouani, and Zhiping Yang, and Amy Imrich, and Yaoyu Ning, and Guozhong Qin, and Lester Kobzik
Macrophage scavenger receptor SR-AI contributes to the clearance of von Willebrand factor.
April 2018, Haematologica,
Mohamed S Arredouani, and Zhiping Yang, and Amy Imrich, and Yaoyu Ning, and Guozhong Qin, and Lester Kobzik
Scavenger receptor SR-BI in macrophage lipid metabolism.
July 2011, Atherosclerosis,
Mohamed S Arredouani, and Zhiping Yang, and Amy Imrich, and Yaoyu Ning, and Guozhong Qin, and Lester Kobzik
The class A macrophage scavenger receptor type I (SR-AI) recognizes complement iC3b and mediates NF-κB activation.
February 2010, Protein & cell,
Mohamed S Arredouani, and Zhiping Yang, and Amy Imrich, and Yaoyu Ning, and Guozhong Qin, and Lester Kobzik
Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor.
March 2018, PLoS pathogens,
Mohamed S Arredouani, and Zhiping Yang, and Amy Imrich, and Yaoyu Ning, and Guozhong Qin, and Lester Kobzik
Adenovirus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor (SR-AI) in LDL receptor knock-out mice.
July 2003, Atherosclerosis,
Mohamed S Arredouani, and Zhiping Yang, and Amy Imrich, and Yaoyu Ning, and Guozhong Qin, and Lester Kobzik
Scavenger receptor AI/II truncation, lung function and COPD: a large population-based study.
March 2011, Journal of internal medicine,
Mohamed S Arredouani, and Zhiping Yang, and Amy Imrich, and Yaoyu Ning, and Guozhong Qin, and Lester Kobzik
Disparate regulation and function of the class A scavenger receptors SR-AI/II and MARCO.
December 2005, Journal of immunology (Baltimore, Md. : 1950),
Mohamed S Arredouani, and Zhiping Yang, and Amy Imrich, and Yaoyu Ning, and Guozhong Qin, and Lester Kobzik
Macrophage cholesterol metabolism, apolipoprotein E, and scavenger receptor AI/II mRNA in atherosclerosis-susceptible and -resistant mice.
November 2000, Arteriosclerosis, thrombosis, and vascular biology,
Copied contents to your clipboard!