Fish collected from five different locations from the Calicut region, India were analysed for the levels of organochlorine pesticides (OCPs) and heavy metal (HM) residues in order to elucidate the status of these chemical contaminants in fish and shellfish meant for human consumption. The highest concentrations of OCPs detected in the edible portion of fish were 10.47, 70.57 and 28.35 ng g-1 wet weight, in marine, brackish water and freshwater, respectively. BHC and heptachlor epoxide formed the major share of OCPs in the marine fish while BHCs contributed to the major share in the freshwater and brackish water fish. The DDT (sum of DDT and its metabolites) ranged from 0.05 to 8 ng g-1 in the samples irrespective of the habitat. Among the HMs, Cu, Zn, Mn and Cr were present in the samples irrespective of the place of collection. About 22% of the samples from the freshwater area contained marginally higher lead content above the legal limit of 0.2-0.4 microg g-1. The Cr content ranged from 0.1 to 1.1 microg g-1 in the fish with marginally higher content in the fish from freshwater and marine regions (0.55-1.1 microg g-1). Mercury was detected in the samples (55%) from marine habitat only. The concentrations of OCPs and HMs in the samples, in general, were below the maximum residual level recommended by various organizations.