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Development of inactivated poliovirus vaccine derived from Sabin strains. 2006
B Simizu, and
S Abe, and
H Yamamoto, and
Y Tano, and
Y Ota, and
M Miyazawa, and
H Horie, and
K Satoh, and
K Wakabayashi
Japan Poliomyelitis Research Institute, 5-34-4, Kumegawa-cho, Higashi-murayama, Tokyo 189-0003, Japan.
In the course of Sabin-inactivated poliovirus vaccine (S-IPV) development, we have established high-yield virus production techniques based on Vero cell micro-carrier cultures. Development of specific ELISA tests to quantify the antigen content of S-IPV has been achieved. To adjust the immunogenicity of S-IPV so as to be comparable with the conventional-IPV, a new formulation was determined using a potency test using rats. The reformulated S-IPV was shown to be efficacious for the immunization of monkeys.
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Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology,
