Biomaterial Database

Total lymphocyte count and subpopulation lymphocyte count in relation to blood bicarbonate concentration in peritoneal dialysis patients. 2005

Alicja E Grzegorzewska, and Magdalena Leander

Department of Nephrology, Transplantology and Internal Diseases, Karol Marcinkowski University of Medical Sciences, Poznań, Poland. alicja_grzegorzewska@yahoo.com

Metabolic acidosis negatively influences dietary intake, increases protein catabolism, and deteriorates nutritional status. In the present study, we evaluated in peritoneal dialysis (PD) patients whether parameters of blood acid-base equilibrium influence total and subpopulation lymphocyte counts (TLC, SLCs), which are markers of the immunologic and nutritional status of dialyzed patients. Studies were carried out in 55 patients, mean age 50.9 +/- 12.4 years, treated with PD for a mean of 22.2 +/- 11.4 months. Parameters of blood acid-base equilibrium were measured simultaneously with evaluation of TLC and SLCs. (Antigens CD3, CD4, CD5, CD8, CD19, CD16+56 were determined using flow cytometry.) The study patients showed compensated metabolic acidosis (pH: 7.40 +/- 0.04; HCO3-: 22.9 +/- 2.4 mmol/L). Statistical analysis revealed significant (p < 0.05) positive correlations of bicarbonate blood concentration and base excess with TLC and with CD3, CD5, and CD8 cell counts, but not with CD19 and CD16+56 cell counts. The CD4 cell count correlated only with blood bicarbonate level. Patients on PD who show better correction of metabolic acidosis also show higher TLC and CD3, CD4, CD5, and CD8 cell counts. The numbers of B lymphocytes (CD19) and natural killer cells (CD16+56) are not directly related to bicarbonate blood concentration, at least in the examined range.

UI	MeSH Term	Description	Entries
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010530	Peritoneal Dialysis	Dialysis fluid being introduced into and removed from the peritoneal cavity as either a continuous or an intermittent procedure.	Dialyses, Peritoneal,Dialysis, Peritoneal,Peritoneal Dialyses
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006863	Hydrogen-Ion Concentration	The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH	pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D000136	Acid-Base Equilibrium	The balance between acids and bases in the BODY FLUIDS. The pH (HYDROGEN-ION CONCENTRATION) of the arterial BLOOD provides an index for the total body acid-base balance.	Anion Gap,Acid-Base Balance,Acid Base Balance,Acid Base Equilibrium,Anion Gaps,Balance, Acid-Base,Equilibrium, Acid-Base,Gap, Anion,Gaps, Anion
D000138	Acidosis	A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.	Metabolic Acidosis,Acidoses,Acidoses, Metabolic,Acidosis, Metabolic,Metabolic Acidoses
D001639	Bicarbonates	Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.	Bicarbonate,Bicarbonate Ions,Hydrogen Carbonates,Bicarbonate Ion,Carbonic Acid Ions,Hydrogen Carbonate,Carbonate, Hydrogen,Carbonates, Hydrogen,Ion, Bicarbonate,Ions, Bicarbonate,Ions, Carbonic Acid
D014511	Uremia	A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.	Uremias
D015703	Antigens, CD	Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.	CD Antigen,Cluster of Differentiation Antigen,Cluster of Differentiation Marker,Differentiation Antigens, Leukocyte, Human,Leukocyte Differentiation Antigens, Human,Cluster of Differentiation Antigens,Cluster of Differentiation Markers,Antigen Cluster, Differentiation,Antigen, CD,CD Antigens,Differentiation Antigen Cluster,Differentiation Marker Cluster,Marker Cluster, Differentiation
D016131	Lymphocyte Subsets	A classification of lymphocytes based on structurally or functionally different populations of cells.	Lymphocyte Subpopulations,Lymphocyte Subpopulation,Lymphocyte Subset,Subpopulation, Lymphocyte,Subpopulations, Lymphocyte,Subset, Lymphocyte,Subsets, Lymphocyte