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Cordycepin (3'-deoxyadenosine) was previously shown to inhibit virus production induced by iododeoxyuridine from murine fibroblasts (Wu et al., 1972). We now report that the inhibitory effect of cordycepin results in a reduction of the number of cells producing virus as measured by the infectious center assay and fluorescent antibody technique. Cordycepin has a much greater inhibitory effect on viral replication than on transformation of normal rat kidney cells by murine sarcoma virus since viral production was greatly reduced (seven- to 35-fold) with 5-10 mug/ml of cordycepin while viral transformation was only slightly inhibited (two-fold reduction in focus-forming units) with the same concentration of cordycepin. Inhibition of viral production is most effective if the compound is present during the first 24 h after injection.
L S Richardson, and
R C Ting, and
R C Gallo, and
A M Wu
October 1973,
Virology,
L S Richardson, and
R C Ting, and
R C Gallo, and
A M Wu
January 1974,
International review of cytology,
L S Richardson, and
R C Ting, and
R C Gallo, and
A M Wu
January 1978,
Advances in cancer research,
L S Richardson, and
R C Ting, and
R C Gallo, and
A M Wu
June 1974,
Journal of virology,
L S Richardson, and
R C Ting, and
R C Gallo, and
A M Wu
May 1972,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie,
L S Richardson, and
R C Ting, and
R C Gallo, and
A M Wu
January 1974,
Advances in cancer research,
L S Richardson, and
R C Ting, and
R C Gallo, and
A M Wu
January 1974,
Biochemical and biophysical research communications,
L S Richardson, and
R C Ting, and
R C Gallo, and
A M Wu
May 1971,
Proceedings of the National Academy of Sciences of the United States of America,
L S Richardson, and
R C Ting, and
R C Gallo, and
A M Wu
January 1977,
Texas reports on biology and medicine,
L S Richardson, and
R C Ting, and
R C Gallo, and
A M Wu
March 1977,
Annals of the New York Academy of Sciences,
