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Two patients with history of intravenous drug use and pulmonary talc granulomatosis are presented. The first patient is a black female who was found to have increased activity of serum angiotensin converting enzyme, in addition to other clinical manifestations of sarcoidosis. The second patient is a Hispanic male smoker who presented with a solitary lung nodule and underwent transbronchial biopsies on two separate occasions with the diagnosis of talc granulomatosis. The lung nodule was found to be an adenocarcinoma on resection. Both patients had lung functions consistent with obstructive airways disease.
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