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Dibutyryl cyclic AMP and theophylline kill S49.1 mouse lymphoma tissue culture cells. When cells are grown in soft agar with these drugs, the few clones that survive are resistant to cytolysis. The rate of mutation to resistance is 1-3 times 10-7/cell/generation in both diploid and tetraploid cells. The incidence of mutants is increased by treatment with a chemical mutagen, ICR 191. The mutation is consistently associated with greatly reduced or absent cytoplasmic cyclic AMP binding protein. These results suggest that a somatic mutation leads to a defect of the protein kinase regulatory subunit and that activity of this kinase is required for induction of cell death by cyclic AMP.
P Coffino, and
H R Bourne, and
G M Tomkins
May 1977,
Cell,
P Coffino, and
H R Bourne, and
G M Tomkins
September 1977,
The Journal of biological chemistry,
P Coffino, and
H R Bourne, and
G M Tomkins
January 1987,
Clinical therapeutics,
P Coffino, and
H R Bourne, and
G M Tomkins
October 1979,
Developmental biology,
P Coffino, and
H R Bourne, and
G M Tomkins
January 1970,
Annual review of pharmacology,
P Coffino, and
H R Bourne, and
G M Tomkins
March 1972,
The Journal of endocrinology,
P Coffino, and
H R Bourne, and
G M Tomkins
November 1972,
Rinsho byori. The Japanese journal of clinical pathology,
P Coffino, and
H R Bourne, and
G M Tomkins
May 1972,
Saishin igaku. Modern medicine,
P Coffino, and
H R Bourne, and
G M Tomkins
January 1972,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
P Coffino, and
H R Bourne, and
G M Tomkins
September 1977,
The Journal of biological chemistry,
