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This study was undertaken to determine the effects of somatostatin 201-995 (SMS) on the maintenance dose of intravenous cyclosporine and on graft blood flow, exocrine secretion, and rejection after porcine pancreaticoduodenal allotransplantation (PDA). For seven days, 12 pigs (6 control, 6 SMS-treated) were studied to determine the effects of SMS on serum CsA concentrations. Twenty-six pigs (14 control, 12 SMS) with streptozocin-induced diabetes underwent PDA. Blood flow was measured through graft celiac and superior mesenteric arteries 15 and 60 min after reperfusion. SMS (75 micrograms s.c.) was given after the 15-min blood-flow measurement in the SMS group. Sixteen pigs (8 control, 8 SMS) were followed postoperatively with daily measurements of serum glucose and amylase concentrations, and urine amylase and trypsin activities. All pigs were immunosuppressed with azathioprine, prednisone, and i.v. CsA. SMS pigs also received SMS (75 micrograms s.c.) every 8 hr. SMS had no effect on maintenance dose of CsA or on serum amylase, urine amylase, or urine trypsin activities. Mean days to rejection were also not affected. Intraoperative graft blood flow was significantly decreased by SMS, but incidence of graft thrombosis was unchanged. These results suggest that in the porcine PDA model, SMS does not appear to inhibit exocrine secretion and potentially may adversely affect the early course of PDA by decreasing graft blood flow.
C P Nicholson, and
D Barr, and
M R Oeltjen, and
S R Munn, and
E P DiMagno, and
H A Carpenter, and
M G Sarr, and
J D Perkins
February 1989,
Harefuah,
C P Nicholson, and
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M R Oeltjen, and
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E P DiMagno, and
H A Carpenter, and
M G Sarr, and
J D Perkins
December 1988,
Surgery,
C P Nicholson, and
D Barr, and
M R Oeltjen, and
S R Munn, and
E P DiMagno, and
H A Carpenter, and
M G Sarr, and
J D Perkins
December 2002,
Journal of neuroimmunology,
C P Nicholson, and
D Barr, and
M R Oeltjen, and
S R Munn, and
E P DiMagno, and
H A Carpenter, and
M G Sarr, and
J D Perkins
September 1994,
The Clinical investigator,
C P Nicholson, and
D Barr, and
M R Oeltjen, and
S R Munn, and
E P DiMagno, and
H A Carpenter, and
M G Sarr, and
J D Perkins
June 1990,
The British journal of surgery,
C P Nicholson, and
D Barr, and
M R Oeltjen, and
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E P DiMagno, and
H A Carpenter, and
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J D Perkins
January 1990,
Gut,
C P Nicholson, and
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M R Oeltjen, and
S R Munn, and
E P DiMagno, and
H A Carpenter, and
M G Sarr, and
J D Perkins
January 1998,
International ophthalmology,
C P Nicholson, and
D Barr, and
M R Oeltjen, and
S R Munn, and
E P DiMagno, and
H A Carpenter, and
M G Sarr, and
J D Perkins
May 1987,
The American journal of medicine,
C P Nicholson, and
D Barr, and
M R Oeltjen, and
S R Munn, and
E P DiMagno, and
H A Carpenter, and
M G Sarr, and
J D Perkins
January 1990,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
C P Nicholson, and
D Barr, and
M R Oeltjen, and
S R Munn, and
E P DiMagno, and
H A Carpenter, and
M G Sarr, and
J D Perkins
July 1987,
The Korean journal of internal medicine,
