Intracerebroventricular injection of neuropeptide Y modifies carbohydrate and lipid metabolism in chicks. 2006

Tetsuya Tachibana, and Momoka Sato, and Daichi Oikawa, and Hirokazu Takahashi, and Tim Boswell, and Mitsuhiro Furuse
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan. tetsu@brs.kyushu-u.ac.jp

The purpose of the present study was to investigate whether intracerebroventricular (ICV) injection of neuropeptide Y (NPY) affects heat production (HP), body temperature, and plasma concentrations of metabolic fuels in chicks. ICV injection of NPY (0, 188 or 375 pmol) did not affect HP, but significantly lowered respiratory quotient as well as the rectal temperature. These data suggest that the energy sources for HP were modified by NPY in the body. This idea was confirmed by subsequent experiments in which ICV injection of NPY significantly reduced plasma glucose and triacylglycerol concentrations but increased non-esterified fatty acid concentrations. The effect of NPY on the utilization of metabolic fuels was not associated changes in plasma catecholamine and corticosterone concentrations. In summary, the present study demonstrated that central NPY modifies peripheral carbohydrate and lipid metabolism in chicks.

UI MeSH Term Description Entries
D007276 Injections, Intraventricular Injections into the cerebral ventricles. Intraventricular Injections,Injection, Intraventricular,Intraventricular Injection
D008297 Male Males
D009478 Neuropeptide Y A 36-amino acid peptide present in many organs and in many sympathetic noradrenergic neurons. It has vasoconstrictor and natriuretic activity and regulates local blood flow, glandular secretion, and smooth muscle activity. The peptide also stimulates feeding and drinking behavior and influences secretion of pituitary hormones. Neuropeptide Y-Like Immunoreactive Peptide,Neuropeptide Tyrosine,Neuropeptide Y Like Immunoreactive Peptide,Tyrosine, Neuropeptide
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D001831 Body Temperature The measure of the level of heat of a human or animal. Organ Temperature,Body Temperatures,Organ Temperatures,Temperature, Body,Temperature, Organ,Temperatures, Body,Temperatures, Organ
D002241 Carbohydrates A class of organic compounds composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n. The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrate
D002645 Chickens Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA. Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004333 Drug Administration Routes The various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and delivered to the target tissue. Administration Routes, Drug,Administration Route, Drug,Drug Administration Route,Route, Drug Administration,Routes, Drug Administration
D005227 Fatty Acids Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed) Aliphatic Acid,Esterified Fatty Acid,Fatty Acid,Fatty Acids, Esterified,Fatty Acids, Saturated,Saturated Fatty Acid,Aliphatic Acids,Acid, Aliphatic,Acid, Esterified Fatty,Acid, Saturated Fatty,Esterified Fatty Acids,Fatty Acid, Esterified,Fatty Acid, Saturated,Saturated Fatty Acids

Related Publications

Tetsuya Tachibana, and Momoka Sato, and Daichi Oikawa, and Hirokazu Takahashi, and Tim Boswell, and Mitsuhiro Furuse
February 1991, The American journal of physiology,
Tetsuya Tachibana, and Momoka Sato, and Daichi Oikawa, and Hirokazu Takahashi, and Tim Boswell, and Mitsuhiro Furuse
August 2007, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology,
Tetsuya Tachibana, and Momoka Sato, and Daichi Oikawa, and Hirokazu Takahashi, and Tim Boswell, and Mitsuhiro Furuse
May 1999, Regulatory peptides,
Tetsuya Tachibana, and Momoka Sato, and Daichi Oikawa, and Hirokazu Takahashi, and Tim Boswell, and Mitsuhiro Furuse
October 2021, Neuropeptides,
Tetsuya Tachibana, and Momoka Sato, and Daichi Oikawa, and Hirokazu Takahashi, and Tim Boswell, and Mitsuhiro Furuse
January 1986, Physiology & behavior,
Tetsuya Tachibana, and Momoka Sato, and Daichi Oikawa, and Hirokazu Takahashi, and Tim Boswell, and Mitsuhiro Furuse
February 1997, Journal of neuroendocrinology,
Tetsuya Tachibana, and Momoka Sato, and Daichi Oikawa, and Hirokazu Takahashi, and Tim Boswell, and Mitsuhiro Furuse
October 1994, Brain research,
Tetsuya Tachibana, and Momoka Sato, and Daichi Oikawa, and Hirokazu Takahashi, and Tim Boswell, and Mitsuhiro Furuse
July 1996, Journal of neuroendocrinology,
Tetsuya Tachibana, and Momoka Sato, and Daichi Oikawa, and Hirokazu Takahashi, and Tim Boswell, and Mitsuhiro Furuse
October 2010, Neuroscience letters,
Tetsuya Tachibana, and Momoka Sato, and Daichi Oikawa, and Hirokazu Takahashi, and Tim Boswell, and Mitsuhiro Furuse
August 2016, Endocrinology,
Copied contents to your clipboard!