Cytomegalovirus infection in lung transplant patients: the role of prophylaxis and recipient-donor serotype matching. 2006

Christopher M Burton, and Pernille Kristensen, and Rikke Lützhøft, and Mette Rasmussen, and Nils Milman, and Jørn Carlsen, and Claus Bohn Christiansen, and Claus B Andersen, and Martin Iversen
Division of Lung Transplantation, Department of Medicine B, Rigshospitalet, Copenhagen, Denmark. cmburton@doctors.net.uk

Cytomegalovirus (CMV) remains an important cause of morbidity and mortality in lung transplant recipients. We investigated the incidence of CMV infection in relation to CMV prophylaxis, and recipient-donor CMV serotype, in a cohort of 250 consecutive lung transplant recipients. All patients received 3 months CMV prophylaxis with acyclovir (n = 67) or gancyclovir (n = 183). Recipient-donor CMV serotype matching was performed in patients receiving acyclovir: R+/D+(n = 38), R+/D-(n = 10), R-/D+(n = 1), R- /D-(n = 16), unknown (n = 2). Recipient-donor CMV serotype matching was not performed in patients receiving gancyclovir: R+/D+(n = 71), R+/D-(n = 42), R-/D+(n = 38), R-/D-(n = 31), unknown (n = 1). The overall incidence of CMV infection was 51% (n = 34) in the acyclovir group, and 42% (n = 77) in the gancyclovir group (p = 0.14). During the first 9 months after transplantation, the rate of CMV infection was higher in the acyclovir group (42%) compared with the gancyclovir group (30%) (p = 0.005). Multivariate analysis demonstrated the incidence of CMV infection during the first 9 months was higher for acyclovir prophylaxis (p<0.001) and R-/D+ serostatus (p<0.001) and lower with R-/D- serostatus (p = 0.02). In conclusion, gancyclovir significantly delays the onset of first CMV infection among lung transplant patients. CMV surveillance and choice of prophylaxis may be modified according to donor-recipient CMV serotype.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D001788 Blood Grouping and Crossmatching Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion. Blood Typing,Crossmatching, Blood,Blood Grouping,Blood Crossmatching,Grouping, Blood,Typing, Blood
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D003586 Cytomegalovirus Infections Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults. CMV Inclusion,CMV Inclusions,Congenital CMV Infection,Congenital Cytomegalovirus Infection,Cytomegalic Inclusion Disease,Cytomegalovirus Colitis,Cytomegalovirus Inclusion,Cytomegalovirus Inclusion Disease,Cytomegalovirus Inclusions,Inclusion Disease,Perinatal CMV Infection,Perinatal Cytomegalovirus Infection,Renal Tubular Cytomegalovirus Inclusion,Renal Tubular Cytomegalovirus Inclusions,Salivary Gland Virus Disease,Severe Cytomegalovirus Infection,Severe Cytomegalovirus Infections,Infections, Cytomegalovirus,CMV Infection, Congenital,CMV Infection, Perinatal,Colitis, Cytomegalovirus,Congenital CMV Infections,Congenital Cytomegalovirus Infections,Cytomegalic Inclusion Diseases,Cytomegalovirus Colitides,Cytomegalovirus Inclusion Diseases,Cytomegalovirus Infection,Cytomegalovirus Infection, Congenital,Cytomegalovirus Infection, Perinatal,Cytomegalovirus Infection, Severe,Cytomegalovirus Infections, Severe,Disease, Cytomegalic Inclusion,Disease, Cytomegalovirus Inclusion,Diseases, Cytomegalovirus Inclusion,Inclusion Disease, Cytomegalic,Inclusion Disease, Cytomegalovirus,Inclusion Diseases,Inclusion Diseases, Cytomegalovirus,Inclusion, CMV,Inclusion, Cytomegalovirus,Infection, Congenital CMV,Infection, Congenital Cytomegalovirus,Infection, Cytomegalovirus,Infection, Perinatal CMV,Infection, Perinatal Cytomegalovirus,Infection, Severe Cytomegalovirus,Perinatal CMV Infections,Perinatal Cytomegalovirus Infections
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000212 Acyclovir A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes. Acycloguanosine,9-((2-Hydroxyethoxy)methyl)guanine,Aci-Sanorania,Acic,Aciclobeta,Aciclostad,Aciclovir,Aciclovir Alonga,Aciclovir-Sanorania,Acifur,Acipen Solutab,Acivir,Activir,Acyclo-V,Acyclovir Sodium,Antiherpes Creme,Avirax,Cicloferon,Clonorax,Cusiviral,Genvir,Herpetad,Herpofug,Herpotern,Herpoviric,Isavir,Laciken,Mapox,Maynar,Milavir,Opthavir,Supraviran,Viclovir,Vipral,Virax-Puren,Virherpes,Virmen,Virolex,Virupos,Virzin,Wellcome-248U,Zoliparin,Zovirax,Zyclir,aciclovir von ct,Aci Sanorania,Aciclovir Sanorania,Acyclo V,Alonga, Aciclovir,Sodium, Acyclovir,Solutab, Acipen,Virax Puren,ViraxPuren,Wellcome 248U,Wellcome248U
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

Christopher M Burton, and Pernille Kristensen, and Rikke Lützhøft, and Mette Rasmussen, and Nils Milman, and Jørn Carlsen, and Claus Bohn Christiansen, and Claus B Andersen, and Martin Iversen
October 1992, Medicina clinica,
Christopher M Burton, and Pernille Kristensen, and Rikke Lützhøft, and Mette Rasmussen, and Nils Milman, and Jørn Carlsen, and Claus Bohn Christiansen, and Claus B Andersen, and Martin Iversen
September 2010, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
Christopher M Burton, and Pernille Kristensen, and Rikke Lützhøft, and Mette Rasmussen, and Nils Milman, and Jørn Carlsen, and Claus Bohn Christiansen, and Claus B Andersen, and Martin Iversen
November 2000, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
Christopher M Burton, and Pernille Kristensen, and Rikke Lützhøft, and Mette Rasmussen, and Nils Milman, and Jørn Carlsen, and Claus Bohn Christiansen, and Claus B Andersen, and Martin Iversen
August 2016, Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation,
Christopher M Burton, and Pernille Kristensen, and Rikke Lützhøft, and Mette Rasmussen, and Nils Milman, and Jørn Carlsen, and Claus Bohn Christiansen, and Claus B Andersen, and Martin Iversen
November 2020, Current opinion in nephrology and hypertension,
Christopher M Burton, and Pernille Kristensen, and Rikke Lützhøft, and Mette Rasmussen, and Nils Milman, and Jørn Carlsen, and Claus Bohn Christiansen, and Claus B Andersen, and Martin Iversen
November 2021, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
Christopher M Burton, and Pernille Kristensen, and Rikke Lützhøft, and Mette Rasmussen, and Nils Milman, and Jørn Carlsen, and Claus Bohn Christiansen, and Claus B Andersen, and Martin Iversen
November 2014, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases,
Christopher M Burton, and Pernille Kristensen, and Rikke Lützhøft, and Mette Rasmussen, and Nils Milman, and Jørn Carlsen, and Claus Bohn Christiansen, and Claus B Andersen, and Martin Iversen
April 2015, Transplant infectious disease : an official journal of the Transplantation Society,
Christopher M Burton, and Pernille Kristensen, and Rikke Lützhøft, and Mette Rasmussen, and Nils Milman, and Jørn Carlsen, and Claus Bohn Christiansen, and Claus B Andersen, and Martin Iversen
January 2018, IDCases,
Christopher M Burton, and Pernille Kristensen, and Rikke Lützhøft, and Mette Rasmussen, and Nils Milman, and Jørn Carlsen, and Claus Bohn Christiansen, and Claus B Andersen, and Martin Iversen
August 2022, Minerva surgery,
Copied contents to your clipboard!