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Since a number of rat hepatocarcinomas are aneuploid, the model DNA content of enzyme-altered foci was determined cytospectrophotometrically, to assess if ploidy changes occur before cancer is established. Male F344 rats treated with diethylnitrosamine and promoted with a choline-deficient, phenobarbital supplemented diet showed in most enzyme-altered foci a multimodal ploidy distribution with diploid, tetraploid and octoploid peaks. A minority of foci, however, exhibited an aneuploid pattern. This change in ploidy reflects irreversible genomic alterations, indicative of tumor progression. Thus, promotion and progression may coexist simultaneously in this model of carcinogenesis, long before hepatomas can be diagnosed.
O Sudilovsky, and
T K Hei
July 1999,
Toxicology letters,
O Sudilovsky, and
T K Hei
April 1983,
Environmental health perspectives,
O Sudilovsky, and
T K Hei
September 2008,
Japanese journal of clinical oncology,
O Sudilovsky, and
T K Hei
November 1996,
Japanese journal of cancer research : Gann,
O Sudilovsky, and
T K Hei
October 2004,
International journal of experimental pathology,
O Sudilovsky, and
T K Hei
August 1994,
Cancer letters,
O Sudilovsky, and
T K Hei
January 1971,
Histochemie. Histochemistry. Histochimie,
O Sudilovsky, and
T K Hei
July 1995,
Mutation research,
O Sudilovsky, and
T K Hei
February 2005,
Liver international : official journal of the International Association for the Study of the Liver,
O Sudilovsky, and
T K Hei
April 1988,
Carcinogenesis,
