Estrogen receptor polymorphisms in tamoxifen-treated women with breast cancer. 2006

Neoklis A Georgopoulos, and George L Adonakis, and Andreas Fotopoulos, and Vasiliki Koika, and Nikitas Spinos, and Alexandros Saltamavros, and Antonios Keramopoulos, and Dimitrios Koukouras, and George Decavalas, and George S Kourounis
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Patras Medical School, Greece. neoklisg@hol.gr

In postmenopausal women with estrogen receptor (ER)-positive breast cancer, long-term tamoxifen administration has proved beneficial after surgical treatment and subsequent chemotherapy. One of the major adverse effects of tamoxifen is the development of endometrial pathology (polyps, endometrial hyperplasia and endometrial cancer). PvuII and XbaI polymorphisms of the estrogen receptor-alpha gene (ERalpha) and RsaI and AluI polymorphisms of the estrogen receptor-beta gene (ERbeta) have been associated with breast cancer. Thus the present study aimed to identify whether ER gene polymorphisms are associated with breast cancer stage or endometrial responsiveness to long-term tamoxifen treatment in 87 postmenopausal, tamoxifen-treated women with ER-positive breast cancer. The mean age of the patients was 58.7 +/- 4.7 years and the mean duration of tamoxifen treatment was 3.9 +/- 1.1 years. At diagnosis, the stage of breast cancer was determined as follows: 29 women (32%) at Stage I, 49 (58%) at Stage II and 9 (10%) at Stage III. The frequency distributions of the estrogen receptor polymorphisms in all women with breast cancer were not different from those predicted by the Hardy-Weinberg equilibrium hypothesis (p > 0.10). None of the ER polymorphisms studied was linked to either the presence of endometrial pathology or the stage of breast cancer.

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009367 Neoplasm Staging Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. Cancer Staging,Staging, Neoplasm,Tumor Staging,TNM Classification,TNM Staging,TNM Staging System,Classification, TNM,Classifications, TNM,Staging System, TNM,Staging Systems, TNM,Staging, Cancer,Staging, TNM,Staging, Tumor,System, TNM Staging,Systems, TNM Staging,TNM Classifications,TNM Staging Systems
D011110 Polymorphism, Genetic The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. Gene Polymorphism,Genetic Polymorphism,Polymorphism (Genetics),Genetic Polymorphisms,Gene Polymorphisms,Polymorphism, Gene,Polymorphisms (Genetics),Polymorphisms, Gene,Polymorphisms, Genetic
D001943 Breast Neoplasms Tumors or cancer of the human BREAST. Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D004717 Endometrium The mucous membrane lining of the uterine cavity that is hormonally responsive during the MENSTRUAL CYCLE and PREGNANCY. The endometrium undergoes cyclic changes that characterize MENSTRUATION. After successful FERTILIZATION, it serves to sustain the developing embryo. Endometria
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013629 Tamoxifen One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM. ICI-46,474,ICI-46474,ICI-47699,Nolvadex,Novaldex,Soltamox,Tamoxifen Citrate,Tomaxithen,Zitazonium,Citrate, Tamoxifen,ICI 46,474,ICI 46474,ICI 47699,ICI46,474,ICI46474,ICI47699
D016889 Endometrial Neoplasms Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells. Cancer of Endometrium,Endometrial Cancer,Endometrial Carcinoma,Cancer of the Endometrium,Carcinoma of Endometrium,Endometrium Cancer,Neoplasms, Endometrial,Cancer, Endometrial,Cancer, Endometrium,Cancers, Endometrial,Cancers, Endometrium,Carcinoma, Endometrial,Carcinomas, Endometrial,Endometrial Cancers,Endometrial Carcinomas,Endometrial Neoplasm,Endometrium Cancers,Endometrium Carcinoma,Endometrium Carcinomas,Neoplasm, Endometrial
D047628 Estrogen Receptor alpha One of the ESTROGEN RECEPTORS that has marked affinity for ESTRADIOL. Its expression and function differs from, and in some ways opposes, ESTROGEN RECEPTOR BETA. ERalpha,Estradiol Receptor alpha,Estrogen Receptor 1,Estrogen Receptors alpha,Receptor alpha, Estrogen,Receptor alpha, Estradiol,alpha, Estradiol Receptor

Related Publications

Neoklis A Georgopoulos, and George L Adonakis, and Andreas Fotopoulos, and Vasiliki Koika, and Nikitas Spinos, and Alexandros Saltamavros, and Antonios Keramopoulos, and Dimitrios Koukouras, and George Decavalas, and George S Kourounis
April 2008, Cancer,
Neoklis A Georgopoulos, and George L Adonakis, and Andreas Fotopoulos, and Vasiliki Koika, and Nikitas Spinos, and Alexandros Saltamavros, and Antonios Keramopoulos, and Dimitrios Koukouras, and George Decavalas, and George S Kourounis
May 2008, BMC genomics,
Neoklis A Georgopoulos, and George L Adonakis, and Andreas Fotopoulos, and Vasiliki Koika, and Nikitas Spinos, and Alexandros Saltamavros, and Antonios Keramopoulos, and Dimitrios Koukouras, and George Decavalas, and George S Kourounis
February 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
Neoklis A Georgopoulos, and George L Adonakis, and Andreas Fotopoulos, and Vasiliki Koika, and Nikitas Spinos, and Alexandros Saltamavros, and Antonios Keramopoulos, and Dimitrios Koukouras, and George Decavalas, and George S Kourounis
August 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
Neoklis A Georgopoulos, and George L Adonakis, and Andreas Fotopoulos, and Vasiliki Koika, and Nikitas Spinos, and Alexandros Saltamavros, and Antonios Keramopoulos, and Dimitrios Koukouras, and George Decavalas, and George S Kourounis
September 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
Neoklis A Georgopoulos, and George L Adonakis, and Andreas Fotopoulos, and Vasiliki Koika, and Nikitas Spinos, and Alexandros Saltamavros, and Antonios Keramopoulos, and Dimitrios Koukouras, and George Decavalas, and George S Kourounis
January 1994, Cancer research,
Neoklis A Georgopoulos, and George L Adonakis, and Andreas Fotopoulos, and Vasiliki Koika, and Nikitas Spinos, and Alexandros Saltamavros, and Antonios Keramopoulos, and Dimitrios Koukouras, and George Decavalas, and George S Kourounis
August 1993, Obstetrics and gynecology,
Neoklis A Georgopoulos, and George L Adonakis, and Andreas Fotopoulos, and Vasiliki Koika, and Nikitas Spinos, and Alexandros Saltamavros, and Antonios Keramopoulos, and Dimitrios Koukouras, and George Decavalas, and George S Kourounis
May 2005, European journal of obstetrics, gynecology, and reproductive biology,
Neoklis A Georgopoulos, and George L Adonakis, and Andreas Fotopoulos, and Vasiliki Koika, and Nikitas Spinos, and Alexandros Saltamavros, and Antonios Keramopoulos, and Dimitrios Koukouras, and George Decavalas, and George S Kourounis
January 1994, Obstetrics and gynecology,
Neoklis A Georgopoulos, and George L Adonakis, and Andreas Fotopoulos, and Vasiliki Koika, and Nikitas Spinos, and Alexandros Saltamavros, and Antonios Keramopoulos, and Dimitrios Koukouras, and George Decavalas, and George S Kourounis
January 2004, Geriatric nursing (New York, N.Y.),
Copied contents to your clipboard!