Lymphocytic choriomeningitis virus: an emerging obstetric pathogen? 2006

Denise J Jamieson, and Athena P Kourtis, and Michael Bell, and Sonja A Rasmussen
Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.

A report in May 2005 from the Centers for Disease Control and Prevention describing a cluster of lymphocytic choriomeningitis virus (LCMV) infections among 4 solid organ recipients has increased awareness of and clinical interest in this pathogen. Human infection with LCMV results from direct or indirect contact with rodents. LCMV has particular relevance to obstetrics, as it is likely an under-recognized abortifacient and fetal teratogen. There have been 54 cases of congenital LCMV reported since 1955, with 34 of the cases diagnosed since 1993. Chorioretinitis and hydrocephalus are the predominant characteristics among children diagnosed with congenital LCMV infection. Obstetricians should educate their pregnant patients about the risks of exposure to laboratory, pet, and wild rodents.

UI MeSH Term Description Entries
D008216 Lymphocytic Choriomeningitis A form of meningitis caused by LYMPHOCYTIC CHORIOMENINGITIS VIRUS. MICE and other rodents serve as the natural hosts, and infection in humans usually occurs through inhalation or ingestion of infectious particles. Clinical manifestations include an influenza-like syndrome followed by stiff neck, alterations of mentation, ATAXIA, and incontinence. Maternal infections may result in fetal malformations and injury, including neonatal HYDROCEPHALUS, aqueductal stenosis, CHORIORETINITIS, and MICROCEPHALY. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3) Armstrong Syndrome,Armstrong's Syndrome,Encephalomyelitis, Lymphocytic Choriomeningitis Virus,Lymphocytic Choriomeningitis Virus Encephalomyelitis,Choriomeningitis, Lymphocytic,Syndrome, Armstrong,Syndrome, Armstrong's
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011251 Pregnancy Complications, Infectious The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION. Complications, Infectious Pregnancy,Infectious Pregnancy Complications,Maternal Sepsis,Pregnancy, Infectious Complications,Sepsis during Pregnancy,Sepsis in Pregnancy,Infectious Pregnancy Complication,Pregnancy Complication, Infectious,Sepsis in Pregnancies,Sepsis, Maternal
D004781 Environmental Exposure The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals. Exposure, Environmental,Environmental Exposures,Exposures, Environmental
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000022 Abortion, Spontaneous Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference. Abortion, Tubal,Early Pregnancy Loss,Miscarriage,Spontaneous Abortion,Abortions, Spontaneous,Abortions, Tubal,Early Pregnancy Losses,Loss, Early Pregnancy,Losses, Early Pregnancy,Miscarriages,Pregnancy Loss, Early,Pregnancy Losses, Early,Spontaneous Abortions,Tubal Abortion,Tubal Abortions
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012377 Rodentia A mammalian order which consists of 29 families and many genera. Beavers,Capybaras,Castor Beaver,Dipodidae,Hydrochaeris,Jerboas,Rodents,Beaver,Capybara,Hydrochaeri,Jerboa,Rodent,Rodentias

Related Publications

Denise J Jamieson, and Athena P Kourtis, and Michael Bell, and Sonja A Rasmussen
June 2006, Virologie (Montrouge, France),
Denise J Jamieson, and Athena P Kourtis, and Michael Bell, and Sonja A Rasmussen
January 1995, Emerging infectious diseases,
Denise J Jamieson, and Athena P Kourtis, and Michael Bell, and Sonja A Rasmussen
December 2002, American journal of obstetrics and gynecology,
Denise J Jamieson, and Athena P Kourtis, and Michael Bell, and Sonja A Rasmussen
March 2000, Pediatrics,
Denise J Jamieson, and Athena P Kourtis, and Michael Bell, and Sonja A Rasmussen
May 1992, Archives of pathology & laboratory medicine,
Denise J Jamieson, and Athena P Kourtis, and Michael Bell, and Sonja A Rasmussen
June 1999, The Pediatric infectious disease journal,
Denise J Jamieson, and Athena P Kourtis, and Michael Bell, and Sonja A Rasmussen
January 1996, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
Denise J Jamieson, and Athena P Kourtis, and Michael Bell, and Sonja A Rasmussen
October 2005, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne,
Denise J Jamieson, and Athena P Kourtis, and Michael Bell, and Sonja A Rasmussen
November 1971, Nature: New biology,
Denise J Jamieson, and Athena P Kourtis, and Michael Bell, and Sonja A Rasmussen
May 2021, Tropical medicine and infectious disease,
Copied contents to your clipboard!