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The enzyme activity of serotonin and dopamine synthesis--tryptophan hydroxylase and tyrosine hydroxylase respectively--as well as content of dihydroxyphenylalanine (DOPA) in the brain structures of Wistar and August rat strains were studied in normal conditions and during long-term amphetamine administration (21 day) in dosage of 1.0 mg/kg. Between-strain differences were observed both in normal conditions and during amphetamine using. Inhibition of tyrosine hydroxylase activity, decrease of DOPA and activation of tryptophan hydroxylase activity in the brain structures were found in August rats under amphetamine action. On the contrary, inhibition of tryptophan hydroxylase activity, activation of tyrosine hydroxylase activity and increase of DOPA were revealed in Wistar rats. A relationship between neuronmediator systems metabolism in the brain and peculiarities of behavior and emotional reactivity of the animals during pathological influence was demonstrated.
E L Dovedova, and
D A Khrustalev, and
I E Mel'nikova
December 1956,
Journal of neurochemistry,
E L Dovedova, and
D A Khrustalev, and
I E Mel'nikova
January 2003,
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova,
E L Dovedova, and
D A Khrustalev, and
I E Mel'nikova
January 1964,
Farmakologiia i toksikologiia,
E L Dovedova, and
D A Khrustalev, and
I E Mel'nikova
January 1968,
Voprosy revmatizma,
E L Dovedova, and
D A Khrustalev, and
I E Mel'nikova
February 1982,
JAMA,
E L Dovedova, and
D A Khrustalev, and
I E Mel'nikova
January 1973,
Pediatria,
E L Dovedova, and
D A Khrustalev, and
I E Mel'nikova
January 1983,
Behavioral and neural biology,
E L Dovedova, and
D A Khrustalev, and
I E Mel'nikova
January 1953,
British medical bulletin,
E L Dovedova, and
D A Khrustalev, and
I E Mel'nikova
December 1980,
Pharmacology, biochemistry, and behavior,
E L Dovedova, and
D A Khrustalev, and
I E Mel'nikova
January 1984,
Annual review of pharmacology and toxicology,
