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The new selective D1-dopamine receptor antagonist SCH 39166 was labelled with the positron emitting isotope 11C and used as ligand for visualization of dopamine-D1 receptor binding in Cynomolgus monkeys by PET. After intravenous administration of the ligand a marked uptake of radioactivity was recorded in the D1-dopamine receptor-rich striatum and neocortex but not in the dopamine receptor-poor cerebellum. The uptake of radioactivity in striatum and neocortex was markedly displaced after the intravenous injection of a high dose of the D1-dopamine receptor antagonist SCH 23390 but not after the 5-HT2 receptor antagonist ketanserine. 11C-SCH 39166 should be a useful tool to explore D1-dopamine receptor characteristics in the living human brain by PET.
G Sedvall, and
L Farde, and
A Barnett, and
H Hall, and
C Halldin
January 1992,
Psychopharmacology,
G Sedvall, and
L Farde, and
A Barnett, and
H Hall, and
C Halldin
February 2010,
Bioorganic & medicinal chemistry letters,
G Sedvall, and
L Farde, and
A Barnett, and
H Hall, and
C Halldin
February 2010,
Bioorganic & medicinal chemistry letters,
G Sedvall, and
L Farde, and
A Barnett, and
H Hall, and
C Halldin
January 1987,
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes,
G Sedvall, and
L Farde, and
A Barnett, and
H Hall, and
C Halldin
September 1991,
European journal of pharmacology,
G Sedvall, and
L Farde, and
A Barnett, and
H Hall, and
C Halldin
January 1992,
Psychopharmacology,
G Sedvall, and
L Farde, and
A Barnett, and
H Hall, and
C Halldin
December 1991,
Journal of neurochemistry,
G Sedvall, and
L Farde, and
A Barnett, and
H Hall, and
C Halldin
December 1994,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
G Sedvall, and
L Farde, and
A Barnett, and
H Hall, and
C Halldin
November 1990,
Neuroscience letters,
G Sedvall, and
L Farde, and
A Barnett, and
H Hall, and
C Halldin
August 1996,
Nuclear medicine and biology,
