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We have constructed a genetic linkage map of the long arm of human chromosome 21 comprising 27 DNA markers. This map is an updated version of that reported earlier by group (1989, Genomics 4: 579-591), which contained 17 DNA markers. The current markers consist of 10 genes and 17 anonymous sequences. Traditional methods (restriction fragment length polymorphisms) were used to map 25 of these markers, whereas 2 markers were studied by polymerase chain reaction amplification of (GT)n dinucleotide repeats. Linkage analysis was performed on 40 CEPH families using the computer program packages LINKAGE, CRI-MAP, and MAPMAKER. Recombination rates were significantly different between the sexes, with the male map being 132 cM and the female map being 161 cM, assuming Kosambi interference and a variable ratio of sex difference in recombination. Approximately one-half of the crossovers in either sex occur distally, in terminal band 21q22.3, which also contains 16 of the markers studied. The average distance between adjacent markers was 6 cM.
M B Petersen, and
S A Slaugenhaupt, and
J G Lewis, and
A C Warren, and
A Chakravarti, and
S E Antonarakis
May 1989,
Genomics,
M B Petersen, and
S A Slaugenhaupt, and
J G Lewis, and
A C Warren, and
A Chakravarti, and
S E Antonarakis
August 1988,
Genomics,
M B Petersen, and
S A Slaugenhaupt, and
J G Lewis, and
A C Warren, and
A Chakravarti, and
S E Antonarakis
January 1985,
Annals of the New York Academy of Sciences,
M B Petersen, and
S A Slaugenhaupt, and
J G Lewis, and
A C Warren, and
A Chakravarti, and
S E Antonarakis
November 1989,
Genomics,
M B Petersen, and
S A Slaugenhaupt, and
J G Lewis, and
A C Warren, and
A Chakravarti, and
S E Antonarakis
August 1990,
Proceedings of the National Academy of Sciences of the United States of America,
M B Petersen, and
S A Slaugenhaupt, and
J G Lewis, and
A C Warren, and
A Chakravarti, and
S E Antonarakis
November 1987,
Proceedings of the National Academy of Sciences of the United States of America,
M B Petersen, and
S A Slaugenhaupt, and
J G Lewis, and
A C Warren, and
A Chakravarti, and
S E Antonarakis
November 1988,
Genomics,
M B Petersen, and
S A Slaugenhaupt, and
J G Lewis, and
A C Warren, and
A Chakravarti, and
S E Antonarakis
February 1992,
Genomics,
M B Petersen, and
S A Slaugenhaupt, and
J G Lewis, and
A C Warren, and
A Chakravarti, and
S E Antonarakis
November 1992,
Genomics,
M B Petersen, and
S A Slaugenhaupt, and
J G Lewis, and
A C Warren, and
A Chakravarti, and
S E Antonarakis
April 1994,
Genomics,
