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We have isolated and mapped 75 new DNA markers including 52 restriction fragment length polymorphism (RFLP) markers on human chromosome 3. Clones were mapped by nonisotopic in situ hybridization, in which discrete fluorescent signals can be detected on prometaphase R-banded chromosomes. Thirty-seven markers were mapped to each arm of chromosome 3, and one was localized to the centromere. Five markers defined variable number of tandem repeat (VNTR) loci. Although the 75 clones were scattered throughout the chromosome, they were concentrated in the R-positive bands. This physical map of chromosome 3 will contribute to the characterization of the chromosomal and molecular aberrations involved in renal cell carcinoma, small-cell lung cancer, and other malignancies and in single-gene disorders such as von Hippel-Lindau disease and autosomal dominant retinitis pigmentosa.
K Yamakawa, and
E Takahashi, and
H Saito, and
T Sato, and
M Oshimura, and
T Hori, and
Y Nakamura
May 1995,
Genomics,
K Yamakawa, and
E Takahashi, and
H Saito, and
T Sato, and
M Oshimura, and
T Hori, and
Y Nakamura
August 1992,
Genomics,
K Yamakawa, and
E Takahashi, and
H Saito, and
T Sato, and
M Oshimura, and
T Hori, and
Y Nakamura
February 1991,
American journal of human genetics,
K Yamakawa, and
E Takahashi, and
H Saito, and
T Sato, and
M Oshimura, and
T Hori, and
Y Nakamura
January 1992,
Mammalian genome : official journal of the International Mammalian Genome Society,
K Yamakawa, and
E Takahashi, and
H Saito, and
T Sato, and
M Oshimura, and
T Hori, and
Y Nakamura
January 1992,
American journal of human genetics,
K Yamakawa, and
E Takahashi, and
H Saito, and
T Sato, and
M Oshimura, and
T Hori, and
Y Nakamura
November 1988,
Nucleic acids research,
K Yamakawa, and
E Takahashi, and
H Saito, and
T Sato, and
M Oshimura, and
T Hori, and
Y Nakamura
July 1992,
Genomics,
K Yamakawa, and
E Takahashi, and
H Saito, and
T Sato, and
M Oshimura, and
T Hori, and
Y Nakamura
July 1989,
Nucleic acids research,
K Yamakawa, and
E Takahashi, and
H Saito, and
T Sato, and
M Oshimura, and
T Hori, and
Y Nakamura
October 1988,
Nucleic acids research,
K Yamakawa, and
E Takahashi, and
H Saito, and
T Sato, and
M Oshimura, and
T Hori, and
Y Nakamura
October 1988,
Nucleic acids research,
