BIOMAT Database Logo BIOMAT Database Logo

Effect of carvedilol on venous return: a mechanism of reduction in blood pressure. 1991

T Ishibashi, and M Okuhira, and M Hamaguchi, and N Katsumata, and M Nakazawa, and S Imai
Department of Pharmacology, Niigata University School of Medicine, Japan.

We studied the effect of carvedilol, a beta-blocker with a potent alpha-blocking activity, on venous return in anesthetized dogs. Though 3 micrograms/kg of carvedilol caused a slight increase in blood pressure and total peripheral resistance, these changes disappeared by further doses of the agent. On the other hand, each dose of carvedilol (3-100 micrograms/kg) decreased venous return significantly and dose-dependently. These results indicate that the hypotensive effect of carvedilol mainly depends on the decrease in venous return rather than arterial vasodilation.

UI MeSH Term Description Entries
D008297 Male Males
D011412 Propanolamines AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives. Aminopropanols
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002227 Carbazoles Benzo-indoles similar to CARBOLINES which are pyrido-indoles. In plants, carbazoles are derived from indole and form some of the INDOLE ALKALOIDS.
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005260 Female Females
D006339 Heart Rate The number of times the HEART VENTRICLES contract per unit of time, usually per minute. Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D000077261 Carvedilol A carbazole and propanol derivative that acts as a non-cardioselective beta blocker and vasodilator. It has blocking activity for ALPHA 1 ADRENERGIC RECEPTORS and, at higher doses, may function as a blocker of CALCIUM CHANNELS; it also has antioxidant properties. Carvedilol is used in the treatment of HYPERTENSION; ANGINA PECTORIS; and HEART FAILURE. It can also reduce the risk of death following MYOCARDIAL INFARCTION. BM 14190,BM-14190,Carvedilol Hydrochloride,Carvedilol, (+),Carvedilol, (+)-isomer,Carvedilol, (+-)-isomer,Carvedilol, (-),Carvedilol, (-)-isomer,Carvedilol, (R)-isomer,Carvedilol, (S)-isomer,Carvedilol, 14C-labeled,Coreg,Coropres,Dilatrend,Eucardic,Kredex,Querto,14C-labeled Carvedilol,BM14190,Carvedilol, 14C labeled
D000319 Adrenergic beta-Antagonists Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. Adrenergic beta-Antagonist,Adrenergic beta-Receptor Blockader,Adrenergic beta-Receptor Blockaders,beta-Adrenergic Antagonist,beta-Adrenergic Blocker,beta-Adrenergic Blocking Agent,beta-Adrenergic Blocking Agents,beta-Adrenergic Receptor Blockader,beta-Adrenergic Receptor Blockaders,beta-Adrenoceptor Antagonist,beta-Blockers, Adrenergic,beta-Adrenergic Antagonists,beta-Adrenergic Blockers,beta-Adrenoceptor Antagonists,Adrenergic beta Antagonist,Adrenergic beta Antagonists,Adrenergic beta Receptor Blockader,Adrenergic beta Receptor Blockaders,Adrenergic beta-Blockers,Agent, beta-Adrenergic Blocking,Agents, beta-Adrenergic Blocking,Antagonist, beta-Adrenergic,Antagonist, beta-Adrenoceptor,Antagonists, beta-Adrenergic,Antagonists, beta-Adrenoceptor,Blockader, Adrenergic beta-Receptor,Blockader, beta-Adrenergic Receptor,Blockaders, Adrenergic beta-Receptor,Blockaders, beta-Adrenergic Receptor,Blocker, beta-Adrenergic,Blockers, beta-Adrenergic,Blocking Agent, beta-Adrenergic,Blocking Agents, beta-Adrenergic,Receptor Blockader, beta-Adrenergic,Receptor Blockaders, beta-Adrenergic,beta Adrenergic Antagonist,beta Adrenergic Antagonists,beta Adrenergic Blocker,beta Adrenergic Blockers,beta Adrenergic Blocking Agent,beta Adrenergic Blocking Agents,beta Adrenergic Receptor Blockader,beta Adrenergic Receptor Blockaders,beta Adrenoceptor Antagonist,beta Adrenoceptor Antagonists,beta Blockers, Adrenergic,beta-Antagonist, Adrenergic,beta-Antagonists, Adrenergic,beta-Receptor Blockader, Adrenergic,beta-Receptor Blockaders, Adrenergic

Related Publications

T Ishibashi, and M Okuhira, and M Hamaguchi, and N Katsumata, and M Nakazawa, and S Imai
[Effect of negative intrathoracic pressure on venous return].
January 2001, Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova,
T Ishibashi, and M Okuhira, and M Hamaguchi, and N Katsumata, and M Nakazawa, and S Imai
Peripheral venous pressure and venous return pressure.
July 1973, Japanese circulation journal,
T Ishibashi, and M Okuhira, and M Hamaguchi, and N Katsumata, and M Nakazawa, and S Imai
Effect of carvedilol and metoprolol on blood pressure, blood flow, and vascular resistance.
January 1987, Journal of cardiovascular pharmacology,
T Ishibashi, and M Okuhira, and M Hamaguchi, and N Katsumata, and M Nakazawa, and S Imai
The effect of increased venous return on the venous pressure in patients with congestive heart failure.
April 1950, American heart journal,
T Ishibashi, and M Okuhira, and M Hamaguchi, and N Katsumata, and M Nakazawa, and S Imai
Effect of positive pressure on venous return in volume-loaded cardiac surgical patients.
March 2002, Journal of applied physiology (Bethesda, Md. : 1985),
T Ishibashi, and M Okuhira, and M Hamaguchi, and N Katsumata, and M Nakazawa, and S Imai
Mechanism of action of isoproterenol on venous return.
February 1977, The American journal of physiology,
T Ishibashi, and M Okuhira, and M Hamaguchi, and N Katsumata, and M Nakazawa, and S Imai
Effect of nitroglycerin on peripheral blood flow distribution and venous return.
November 1978, The Journal of pharmacology and experimental therapeutics,
T Ishibashi, and M Okuhira, and M Hamaguchi, and N Katsumata, and M Nakazawa, and S Imai
Effect of nitroprusside on peripheral blood flow distribution and venous return.
January 1978, Clinical and investigative medicine. Medecine clinique et experimentale,
T Ishibashi, and M Okuhira, and M Hamaguchi, and N Katsumata, and M Nakazawa, and S Imai
The effects of arterenol on blood pressure and venous return during extracorporeal circulation.
August 1958, Surgery,
T Ishibashi, and M Okuhira, and M Hamaguchi, and N Katsumata, and M Nakazawa, and S Imai
Effect of venous pressure on forearm blood flow.
September 1968, The Journal of physiology,
Copied contents to your clipboard!