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Electrical field stimulation induced a relaxation response in female rabbit urethral smooth muscle strips precontracted with phenylephrine. The relaxation response was inhibited by tetrodotoxin, but not by atropine, propranolol, or hexamethonium. The relaxation response thus results from stimulation of inhibitory non-adrenergic, non-cholinergic nerves. The electrically induced relaxation response was inhibited by an inhibitor of nitric oxide biosynthesis, NG-nitro-L-arginine. This inhibition was overcome by addition of a precursor of nitric oxide, L-arginine. An inhibitor of soluble guanylate cyclase, methylene blue, reduced the relaxation response, and a selective cyclic GMP phosphodiesterase inhibitor, M & B 22948, potentiated the relaxation response. These data indicate that agents which affect the biosynthesis of nitric oxide are associated with the urethral relaxation response evoked by electrical field stimulation, and that cyclic GMP may mediate the relaxation response.
S Dokita, and
W R Morgan, and
M A Wheeler, and
M Yoshida, and
J Latifpour, and
R M Weiss
August 1990,
British journal of pharmacology,
S Dokita, and
W R Morgan, and
M A Wheeler, and
M Yoshida, and
J Latifpour, and
R M Weiss
March 1991,
Acta physiologica Scandinavica,
S Dokita, and
W R Morgan, and
M A Wheeler, and
M Yoshida, and
J Latifpour, and
R M Weiss
March 1990,
British journal of pharmacology,
S Dokita, and
W R Morgan, and
M A Wheeler, and
M Yoshida, and
J Latifpour, and
R M Weiss
August 1991,
British journal of pharmacology,
S Dokita, and
W R Morgan, and
M A Wheeler, and
M Yoshida, and
J Latifpour, and
R M Weiss
May 1992,
British journal of pharmacology,
S Dokita, and
W R Morgan, and
M A Wheeler, and
M Yoshida, and
J Latifpour, and
R M Weiss
February 1994,
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
S Dokita, and
W R Morgan, and
M A Wheeler, and
M Yoshida, and
J Latifpour, and
R M Weiss
December 1991,
Japanese journal of pharmacology,
S Dokita, and
W R Morgan, and
M A Wheeler, and
M Yoshida, and
J Latifpour, and
R M Weiss
September 1993,
Neuroreport,
S Dokita, and
W R Morgan, and
M A Wheeler, and
M Yoshida, and
J Latifpour, and
R M Weiss
September 1991,
European journal of pharmacology,
S Dokita, and
W R Morgan, and
M A Wheeler, and
M Yoshida, and
J Latifpour, and
R M Weiss
May 1992,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
