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There is evidence that hepatitis C virus (HCV) may be vertically transmitted from infected mothers to their children. To test this hypothesis, we prospectively studied 10 pregnant women at high risk from parenterally or sexually transmitted diseases with the polymerase chain reaction. HCV RNA was found in 8 newborn babies delivered by women who were anti-HCV seropositive, and persisted for 2-19 months of follow-up. Anti-HCV detected in 7 infants cleared by 9 months and remained undetectable thereafter. Serum alanine aminotransferase was raised in 3 infants. The findings provide evidence of vertical transmission of HCV and suggest that perinatal infection may initiate a silent disease process or chronic carrier state.
M M Thaler, and
C K Park, and
D V Landers, and
D W Wara, and
M Houghton, and
G Veereman-Wauters, and
R L Sweet, and
J H Han
August 1994,
The New England journal of medicine,
M M Thaler, and
C K Park, and
D V Landers, and
D W Wara, and
M Houghton, and
G Veereman-Wauters, and
R L Sweet, and
J H Han
June 1997,
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology,
M M Thaler, and
C K Park, and
D V Landers, and
D W Wara, and
M Houghton, and
G Veereman-Wauters, and
R L Sweet, and
J H Han
December 1997,
Anales espanoles de pediatria,
M M Thaler, and
C K Park, and
D V Landers, and
D W Wara, and
M Houghton, and
G Veereman-Wauters, and
R L Sweet, and
J H Han
August 1994,
The New England journal of medicine,
M M Thaler, and
C K Park, and
D V Landers, and
D W Wara, and
M Houghton, and
G Veereman-Wauters, and
R L Sweet, and
J H Han
August 1994,
The New England journal of medicine,
M M Thaler, and
C K Park, and
D V Landers, and
D W Wara, and
M Houghton, and
G Veereman-Wauters, and
R L Sweet, and
J H Han
January 2001,
Anales espanoles de pediatria,
M M Thaler, and
C K Park, and
D V Landers, and
D W Wara, and
M Houghton, and
G Veereman-Wauters, and
R L Sweet, and
J H Han
September 2007,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
M M Thaler, and
C K Park, and
D V Landers, and
D W Wara, and
M Houghton, and
G Veereman-Wauters, and
R L Sweet, and
J H Han
November 2004,
Hepatology research : the official journal of the Japan Society of Hepatology,
M M Thaler, and
C K Park, and
D V Landers, and
D W Wara, and
M Houghton, and
G Veereman-Wauters, and
R L Sweet, and
J H Han
March 1993,
The Journal of infectious diseases,
M M Thaler, and
C K Park, and
D V Landers, and
D W Wara, and
M Houghton, and
G Veereman-Wauters, and
R L Sweet, and
J H Han
January 1996,
Scandinavian journal of infectious diseases,
