-transparent.png){kind=logo}
The effects of general anesthetics and pressure on receptors from the mammalian central nervous system have been investigated using oocyte expression techniques. Poly A+ mRNA extracted from rat whole brain was injected into mature Xenopus oocytes producing depolarizing responses to the fast excitatory neurotransmitters NMDA and kainate and the inhibitory neurotransmitters GABA and glycine. An apparatus was constructed to allow agonist dose-response curves to be determined at high pressures using voltage-clamped oocytes. This was used to investigate the excitatory transmitter kainate. It was found that anesthetics depress the current induced by kainate whereas pressure does not appear to affect the responses associated with this transmitter. Furthermore it was found that pressure does not reverse (or modify in any way) the changes in response brought about by application of anesthetics.
S Daniels, and
D M Zhao, and
N Inman, and
D J Price, and
C J Shelton, and
E B Smith
November 1997,
European journal of pharmacology,
S Daniels, and
D M Zhao, and
N Inman, and
D J Price, and
C J Shelton, and
E B Smith
January 2007,
Pharmacology,
S Daniels, and
D M Zhao, and
N Inman, and
D J Price, and
C J Shelton, and
E B Smith
July 2006,
The Journal of pharmacology and experimental therapeutics,
S Daniels, and
D M Zhao, and
N Inman, and
D J Price, and
C J Shelton, and
E B Smith
January 2002,
Anesthesia and analgesia,
S Daniels, and
D M Zhao, and
N Inman, and
D J Price, and
C J Shelton, and
E B Smith
December 1990,
Molecular pharmacology,
S Daniels, and
D M Zhao, and
N Inman, and
D J Price, and
C J Shelton, and
E B Smith
September 1988,
Molecular pharmacology,
S Daniels, and
D M Zhao, and
N Inman, and
D J Price, and
C J Shelton, and
E B Smith
January 1998,
Molecular pharmacology,
S Daniels, and
D M Zhao, and
N Inman, and
D J Price, and
C J Shelton, and
E B Smith
January 1999,
Advances in experimental medicine and biology,
S Daniels, and
D M Zhao, and
N Inman, and
D J Price, and
C J Shelton, and
E B Smith
June 2007,
Anesthesia and analgesia,
S Daniels, and
D M Zhao, and
N Inman, and
D J Price, and
C J Shelton, and
E B Smith
November 1994,
The Journal of pharmacology and experimental therapeutics,
