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Acute organophosphate pesticide poisonings cause substantial morbidity and mortality world wide; however, whether organophosphates cause chronic neurological sequelae has not been established. To see whether single episodes of acute unintentional organophosphate intoxication lead to chronic neuropsychological dysfunction, we carried out a retrospective study of agricultural workers in Nicaragua who had been admitted to hospital between July 1, 1986, and July 31, 1988, for occupationally related organophosphate intoxication. This "poisoned" group (36 men) was tested on average about two years after the episode of pesticide poisoning and compared with a matched control group. The poisoned group did much worse than the control group on all neuropsychological subtests, with significantly worse performance on five of six subtests of a World Health Organisation neuropsychological test battery and on 3 of 6 additional tests that assessed verbal and visual attention, visual memory, visuomotor speed, sequencing and problem solving, and motor steadiness and dexterity. Differences in neuropsychological performance could not be explained by other factors. The findings of a persistent decrease in neuropsychological performance among individuals with previous intoxication emphasise the importance of prevention of even single episodes of organophosphate poisoning.
L Rosenstock, and
M Keifer, and
W E Daniell, and
R McConnell, and
K Claypoole
January 1977,
Clinical toxicology,
L Rosenstock, and
M Keifer, and
W E Daniell, and
R McConnell, and
K Claypoole
May 1964,
Aerospace medicine,
L Rosenstock, and
M Keifer, and
W E Daniell, and
R McConnell, and
K Claypoole
April 2012,
Environmental health perspectives,
L Rosenstock, and
M Keifer, and
W E Daniell, and
R McConnell, and
K Claypoole
October 1963,
[Report]. Civil Aeromedical Research Institute (U.S.),
L Rosenstock, and
M Keifer, and
W E Daniell, and
R McConnell, and
K Claypoole
October 2004,
Scandinavian journal of work, environment & health,
L Rosenstock, and
M Keifer, and
W E Daniell, and
R McConnell, and
K Claypoole
October 2003,
Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology,
L Rosenstock, and
M Keifer, and
W E Daniell, and
R McConnell, and
K Claypoole
September 1974,
Vrachebnoe delo,
L Rosenstock, and
M Keifer, and
W E Daniell, and
R McConnell, and
K Claypoole
July 2012,
International archives of occupational and environmental health,
L Rosenstock, and
M Keifer, and
W E Daniell, and
R McConnell, and
K Claypoole
April 1999,
Neurology,
L Rosenstock, and
M Keifer, and
W E Daniell, and
R McConnell, and
K Claypoole
January 1988,
Archives of environmental health,
