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Measurements of exposure concentrations of benzene, toluene and xylene, and amounts of respiratory uptake. 2006

Rumiko Murayama, and Sumio Goto, and Daisuke Nakajima, and Hidekazu Fujimaki, and Ikuo Watanabe, and Keiichi Arashidani, and Iwao Uchiyama
Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

With respect to benzene, toluene, and o-, m- and p-xylene contained in indoor air, this study determined the amounts of their uptake through the human respiratory system using the difference between concentrations in inhalation and exhalation, and examined their relationship to concentrations in blood and urine measured before and after exposure. At relatively high concentrations, respiratory absorption of these compounds tended to increase rapidly in the early stage of exposure but decrease after several hours. It was also confirmed that concentrations of these compounds in both blood and urine increased during the first 3 hours of exposure. These results suggested that measurements of concentrations in inhalation and exhalation may provide a simple method for estimating the extent of respiratory exposure to these substances.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D012137 Respiratory System The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about. Respiratory Tract,Respiratory Systems,Respiratory Tracts,System, Respiratory,Tract, Respiratory
D004784 Environmental Monitoring The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment. Monitoring, Environmental,Environmental Surveillance,Surveillance, Environmental
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000042 Absorption The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
D000393 Air Pollutants Any substance in the air which could, if present in high enough concentration, harm humans, animals, vegetation or materials. Substances include GASES; PARTICULATE MATTER; and volatile ORGANIC CHEMICALS. Air Pollutant,Air Pollutants, Environmental,Environmental Air Pollutants,Environmental Pollutants, Air,Air Environmental Pollutants,Pollutant, Air,Pollutants, Air,Pollutants, Air Environmental,Pollutants, Environmental Air
D001554 Benzene Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide. Benzol,Benzole,Cyclohexatriene
D014050 Toluene A widely used industrial solvent.
D014992 Xylenes A family of isomeric, colorless aromatic hydrocarbon liquids, that contain the general formula C6H4(CH3)2. They are produced by the destructive distillation of coal or by the catalytic reforming of petroleum naphthenic fractions. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed) Dimethylbenzenes,Xylene

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