-transparent.png){kind=logo}
1. In two separate studies, each with 12 healthy male volunteers, the pharmacokinetic and dynamic properties of a transdermal delivery system for bopindolol were evaluated. 2. In study I it was shown that bopindolol absorption from a 14 mg patch occurred over the whole 7-day application period. No signs of a significant skin depot were found. 3. In study II, a linear pharmacokinetic behaviour but a non-linear kinetic/dynamic relationship was established for the patches over a dose range from 7 to 21 mg. Comparable peak effects of reduction in exercise-induced tachycardia were observed after different patch doses and an i.v. injection. However, the effect was significantly prolonged with the patches compared with the injection and was maintained over 7 days. 4. The patches showed a good local and systemic tolerability in both studies over a dosing interval of up to 7 days.
J Drewe, and
R Meier, and
U Timonen, and
M Thumshirn, and
J Munzer, and
T Kissel, and
K Gyr
January 1988,
Critical reviews in therapeutic drug carrier systems,
J Drewe, and
R Meier, and
U Timonen, and
M Thumshirn, and
J Munzer, and
T Kissel, and
K Gyr
January 1994,
European journal of clinical pharmacology,
J Drewe, and
R Meier, and
U Timonen, and
M Thumshirn, and
J Munzer, and
T Kissel, and
K Gyr
March 2006,
British journal of clinical pharmacology,
J Drewe, and
R Meier, and
U Timonen, and
M Thumshirn, and
J Munzer, and
T Kissel, and
K Gyr
December 1993,
Journal of clinical pharmacology,
J Drewe, and
R Meier, and
U Timonen, and
M Thumshirn, and
J Munzer, and
T Kissel, and
K Gyr
March 1998,
Drug development and industrial pharmacy,
J Drewe, and
R Meier, and
U Timonen, and
M Thumshirn, and
J Munzer, and
T Kissel, and
K Gyr
May 1988,
British journal of anaesthesia,
J Drewe, and
R Meier, and
U Timonen, and
M Thumshirn, and
J Munzer, and
T Kissel, and
K Gyr
January 2021,
Seminars in radiation oncology,
J Drewe, and
R Meier, and
U Timonen, and
M Thumshirn, and
J Munzer, and
T Kissel, and
K Gyr
January 1983,
Current medical research and opinion,
J Drewe, and
R Meier, and
U Timonen, and
M Thumshirn, and
J Munzer, and
T Kissel, and
K Gyr
September 1996,
German journal of ophthalmology,
J Drewe, and
R Meier, and
U Timonen, and
M Thumshirn, and
J Munzer, and
T Kissel, and
K Gyr
July 1985,
Journal of pharmaceutical sciences,
