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Effects of the alpha 2-adrenoceptor agonists xylazine and detomidine on food intake in freely feeding male rats were evaluated. Intraperitoneal (i.p.) injection of xylazine (0.25-3 mg/kg) and detomidine (25 and 50 micrograms/kg) significantly increased the 2 and 24 h food intake from control values. Treatment of rats with the alpha 2-adrenoceptor antagonist yohimbine (1 mg/kg, i.p.) 15 min before xylazine (0.5 mg/kg, i.p.) or detomidine (50 micrograms/kg, i.p.) significantly inhibited the increase in food intake. Yohimbine treatments alone at 0.5, 1 and 2 mg/kg, i.p. did not significantly change the 2 and 24 h food intake from control values. The results suggest that the alpha 2-agonists xylazine and detomidine enhance food intake in rats.
N H Majeed, and
F K Mohammad, and
R S Ayoub
December 1997,
Journal of veterinary pharmacology and therapeutics,
N H Majeed, and
F K Mohammad, and
R S Ayoub
June 1992,
Journal of veterinary pharmacology and therapeutics,
N H Majeed, and
F K Mohammad, and
R S Ayoub
January 1986,
Acta veterinaria Scandinavica. Supplementum,
N H Majeed, and
F K Mohammad, and
R S Ayoub
October 1992,
Tierarztliche Praxis,
N H Majeed, and
F K Mohammad, and
R S Ayoub
September 1996,
Zentralblatt fur Veterinarmedizin. Reihe A,
N H Majeed, and
F K Mohammad, and
R S Ayoub
June 1981,
European journal of pharmacology,
N H Majeed, and
F K Mohammad, and
R S Ayoub
September 1994,
Zentralblatt fur Veterinarmedizin. Reihe A,
N H Majeed, and
F K Mohammad, and
R S Ayoub
January 1983,
The American journal of physiology,
N H Majeed, and
F K Mohammad, and
R S Ayoub
September 1985,
European journal of pharmacology,
N H Majeed, and
F K Mohammad, and
R S Ayoub
April 1996,
Research communications in molecular pathology and pharmacology,
