BIOMAT Database Logo BIOMAT Database Logo

The interleukin-4 receptor gene (IL4R) maps to 16p11.2-16p12.1 in human and to the distal region of mouse chromosome 7. 1991

M A Pritchard, and E Baker, and S A Whitmore, and G R Sutherland, and R L Idzerda, and L S Park, and D Cosman, and N A Jenkins, and D J Gilbert, and N G Copeland
Department of Cytogenetics and Molecular Genetics, Adelaide Children's Hospital, Australia.

The chromosomal location of both the human and the mouse interleukin-4 receptor (IL4R) genes have been determined. The human gene was localized to 16p11.2-16p12.1 by in situ hybridization and confirmed by Southern blot analysis of DNA from a panel of mouse-human hybrid somatic cell lines. The mouse homolog was positioned in the distal region of chromosome 7 by interspecific backcross analysis. The results suggest that the IL4R locus is unlinked to other members of the hematopoietin receptor family. Interestingly, the position on human chromosome 16 suggests that the IL4R may be a candidate for rearrangements, as 12;16 translocations are often associated with myxoid liposarcomas.

UI MeSH Term Description Entries
D008040 Genetic Linkage The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME. Genetic Linkage Analysis,Linkage, Genetic,Analyses, Genetic Linkage,Analysis, Genetic Linkage,Genetic Linkage Analyses,Linkage Analyses, Genetic,Linkage Analysis, Genetic
D008080 Liposarcoma A malignant tumor derived from primitive or embryonal lipoblastic cells. It may be composed of well-differentiated fat cells or may be dedifferentiated: myxoid (LIPOSARCOMA, MYXOID), round-celled, or pleomorphic, usually in association with a rich network of capillaries. Recurrences are common and dedifferentiated liposarcomas metastasize to the lungs or serosal surfaces. (From Dorland, 27th ed; Stedman, 25th ed) Liposarcoma, Dedifferentiated,Liposarcoma, Pleomorphic,Atypical Lipomatous Tumor,Liposarcoma, Well Differentiated,Well Differentiated Liposarcoma,Atypical Lipomatous Tumors,Dedifferentiated Liposarcoma,Dedifferentiated Liposarcomas,Lipomatous Tumor, Atypical,Liposarcomas,Pleomorphic Liposarcoma,Pleomorphic Liposarcomas,Well Differentiated Liposarcomas
D008297 Male Males
D009115 Muridae A family of the order Rodentia containing 250 genera including the two genera Mus (MICE) and Rattus (RATS), from which the laboratory inbred strains are developed. The fifteen subfamilies are SIGMODONTINAE (New World mice and rats), CRICETINAE, Spalacinae, Myospalacinae, Lophiomyinae, ARVICOLINAE, Platacanthomyinae, Nesomyinae, Otomyinae, Rhizomyinae, GERBILLINAE, Dendromurinae, Cricetomyinae, MURINAE (Old World mice and rats), and Hydromyinae. Murids,Murid
D011975 Receptors, Mitogen Glycoprotein molecules on the surface of B- and T-lymphocytes, that react with molecules of antilymphocyte sera, lectins, and other agents which induce blast transformation of lymphocytes. Lectin Receptors,Mitogen Receptors,Receptors, Lectin,Mitogen Receptor,Receptor, Mitogen
D012150 Polymorphism, Restriction Fragment Length Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment. RFLP,Restriction Fragment Length Polymorphism,RFLPs,Restriction Fragment Length Polymorphisms
D002874 Chromosome Mapping Any method used for determining the location of and relative distances between genes on a chromosome. Gene Mapping,Linkage Mapping,Genome Mapping,Chromosome Mappings,Gene Mappings,Genome Mappings,Linkage Mappings,Mapping, Chromosome,Mapping, Gene,Mapping, Genome,Mapping, Linkage,Mappings, Chromosome,Mappings, Gene,Mappings, Genome,Mappings, Linkage
D002885 Chromosomes, Human, Pair 16 A specific pair of GROUP E CHROMOSOMES of the human chromosome classification. Chromosome 16
D003433 Crosses, Genetic Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species. Cross, Genetic,Genetic Cross,Genetic Crosses
D005260 Female Females

Related Publications

M A Pritchard, and E Baker, and S A Whitmore, and G R Sutherland, and R L Idzerda, and L S Park, and D Cosman, and N A Jenkins, and D J Gilbert, and N G Copeland
Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7.
November 1993, Genomics,
M A Pritchard, and E Baker, and S A Whitmore, and G R Sutherland, and R L Idzerda, and L S Park, and D Cosman, and N A Jenkins, and D J Gilbert, and N G Copeland
The methylenetetrahydrofolate reductase (Mthfr) gene maps to distal mouse chromosome 4.
November 1996, Mammalian genome : official journal of the International Mammalian Genome Society,
M A Pritchard, and E Baker, and S A Whitmore, and G R Sutherland, and R L Idzerda, and L S Park, and D Cosman, and N A Jenkins, and D J Gilbert, and N G Copeland
Mouse B2 bradykinin receptor gene maps to distal chromosome 12.
May 1995, Genomics,
M A Pritchard, and E Baker, and S A Whitmore, and G R Sutherland, and R L Idzerda, and L S Park, and D Cosman, and N A Jenkins, and D J Gilbert, and N G Copeland
The gene for microtubule-associated protein 4 (Mtap4) maps to the distal region of mouse chromosome 9.
December 1996, Mammalian genome : official journal of the International Mammalian Genome Society,
M A Pritchard, and E Baker, and S A Whitmore, and G R Sutherland, and R L Idzerda, and L S Park, and D Cosman, and N A Jenkins, and D J Gilbert, and N G Copeland
The human interleukin-10 receptor gene maps to chromosome 11q23.3.
January 1995, Human genetics,
M A Pritchard, and E Baker, and S A Whitmore, and G R Sutherland, and R L Idzerda, and L S Park, and D Cosman, and N A Jenkins, and D J Gilbert, and N G Copeland
Mouse mitotic spindle checkpoint Bub3 gene maps to the distal region of chromosome 7 by interspecific backcross analysis.
January 1999, Cytogenetics and cell genetics,
M A Pritchard, and E Baker, and S A Whitmore, and G R Sutherland, and R L Idzerda, and L S Park, and D Cosman, and N A Jenkins, and D J Gilbert, and N G Copeland
The gene for mouse p58cdc2L1 (Cdc2l1) protein kinase maps to distal mouse chromosome 4.
March 1994, Mammalian genome : official journal of the International Mammalian Genome Society,
M A Pritchard, and E Baker, and S A Whitmore, and G R Sutherland, and R L Idzerda, and L S Park, and D Cosman, and N A Jenkins, and D J Gilbert, and N G Copeland
The novel gene D4Mil1e maps to mouse chromosome 4 and human chromosome 1p36.
October 1996, Mammalian genome : official journal of the International Mammalian Genome Society,
M A Pritchard, and E Baker, and S A Whitmore, and G R Sutherland, and R L Idzerda, and L S Park, and D Cosman, and N A Jenkins, and D J Gilbert, and N G Copeland
CD19 maps to a region of conservation between human chromosome 16 and mouse chromosome 7.
January 1994, Immunogenetics,
M A Pritchard, and E Baker, and S A Whitmore, and G R Sutherland, and R L Idzerda, and L S Park, and D Cosman, and N A Jenkins, and D J Gilbert, and N G Copeland
The Nfe2l1 gene maps to distal mouse chromosome 11.
January 1996, Mammalian genome : official journal of the International Mammalian Genome Society,
Copied contents to your clipboard!