Complete Klüver-Bucy syndrome in man. 1975

W B Marlowe, and E L Mancall, and J J Thomas

A 22 year old right-handed man suffered a viral meningoencephalitis, possibly herpetic, resulting in bilateral damage to the temporal lobes as confirmed by appropriate clinical, electrophysiological and neuroradiological studies. Extended clinical neuropsychological evaluation documented all the characteristic features of the syndrome described by Klüver and Bucy following bilateral ablation of the temporal lobes in adult Rhesus monkeys, including "psychic blindness," oral exploration, hypermetamorphic impulse to action," lack of emotional responsiveness, aberrant sexual behavior, and an insatiable appetite. Additionally, a severe Wernicke's aphasia and a profound memory disorder were evident. The significance of these features as regards limbic function in the human is discussed.

UI MeSH Term Description Entries
D008297 Male Males
D008569 Memory Disorders Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions. Memory Loss,Age-Related Memory Disorders,Memory Deficits,Memory Disorder, Semantic,Memory Disorder, Spatial,Memory Disorders, Age-Related,Retention Disorders, Cognitive,Semantic Memory Disorder,Spatial Memory Disorder,Age Related Memory Disorders,Age-Related Memory Disorder,Cognitive Retention Disorder,Cognitive Retention Disorders,Deficit, Memory,Deficits, Memory,Memory Deficit,Memory Disorder,Memory Disorder, Age-Related,Memory Disorders, Age Related,Memory Disorders, Semantic,Memory Disorders, Spatial,Memory Losses,Retention Disorder, Cognitive,Semantic Memory Disorders,Spatial Memory Disorders
D008590 Meningoencephalitis An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions. Cerebromeningitis,Encephalomeningitis,Cerebromeningitides,Encephalomeningitides,Meningoencephalitides
D011612 Psychosurgery Treatment of chronic, severe and intractable psychiatric disorders by surgical removal or interruption of certain areas or pathways in the brain, especially in the prefrontal lobes. Gyrectomy,Leucotomy,Leukotomy,Lobotomy,Topectomy,Gyrectomies,Leucotomies,Leukotomies,Lobotomies,Psychosurgeries,Topectomies
D006566 Herpesviridae Infections Virus diseases caused by the HERPESVIRIDAE. Herpesvirus Infections,B Virus Infection,Infections, Herpesviridae,Infections, Herpesvirus,B Virus Infections,Herpesviridae Infection,Herpesvirus Infection,Infection, B Virus,Infection, Herpesviridae,Infection, Herpesvirus,Infections, B Virus
D006716 Homosexuality The sexual attraction or relationship between members of the same SEX. Homosexuality, Ego-Dystonic,Ego-Dystonic Homosexuality,Homosexuality, Ego Dystonic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D001037 Aphasia A cognitive disorder marked by an impaired ability to comprehend or express language in its written or spoken form. This condition is caused by diseases which affect the language areas of the dominant hemisphere. Clinical features are used to classify the various subtypes of this condition. General categories include receptive, expressive, and mixed forms of aphasia. Aphasia, Acquired,Dysphasia,Word Deafness,Alogia,Anepia,Aphasia, Ageusic,Aphasia, Auditory Discriminatory,Aphasia, Commisural,Aphasia, Functional,Aphasia, Global,Aphasia, Graphomotor,Aphasia, Intellectual,Aphasia, Mixed,Aphasia, Post-Ictal,Aphasia, Post-Traumatic,Aphasia, Progressive,Aphasia, Semantic,Aphasia, Syntactical,Dejerine-Lichtheim Phenomenon,Dysphasia, Global,Lichtheim's Sign,Logagnosia,Logamnesia,Logasthenia,Acquired Aphasia,Ageusic Aphasia,Ageusic Aphasias,Alogias,Anepias,Aphasia, Post Ictal,Aphasia, Post Traumatic,Aphasias, Commisural,Auditory Discriminatory Aphasia,Auditory Discriminatory Aphasias,Commisural Aphasia,Commisural Aphasias,Deafness, Word,Dejerine Lichtheim Phenomenon,Discriminatory Aphasia, Auditory,Discriminatory Aphasias, Auditory,Functional Aphasia,Functional Aphasias,Global Aphasia,Global Aphasias,Global Dysphasia,Global Dysphasias,Graphomotor Aphasia,Graphomotor Aphasias,Intellectual Aphasia,Intellectual Aphasias,Lichtheim Sign,Lichtheims Sign,Logagnosias,Logamnesias,Logasthenias,Mixed Aphasia,Mixed Aphasias,Phenomenon, Dejerine-Lichtheim,Post-Ictal Aphasia,Post-Ictal Aphasias,Post-Traumatic Aphasia,Post-Traumatic Aphasias,Progressive Aphasia,Progressive Aphasias,Semantic Aphasia,Semantic Aphasias,Sign, Lichtheim's,Syntactical Aphasia,Syntactical Aphasias
D001068 Feeding and Eating Disorders A group of disorders characterized by physiological and psychological disturbances in appetite or food intake. Appetite Disorders,Eating Disorders,Eating and Feeding Disorders,Feeding Disorders,Appetite Disorder,Disorder, Eating,Disorder, Feeding,Disorders, Eating,Disorders, Feeding,Eating Disorder,Feeding Disorder

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