-transparent.png){kind=logo}
The production of IgE-class antibody specific for polymyxin B is documented in an 18-year-old white female acute myelocytic leukemic patient in relapse. The patient was rendered T cell-deficient by total body X-irradiation and antihuman thymocyte globulin for the purpose of bone marrow transplatation. Thereafter, symptoms of nasal congestion, rhinorrhea, and perinasal urtication produced by topical application of a polymyxin solution were noted. Reaginic activity mediated by an IgE antibody against polymyxin is documented by Prausnbitz-Küstner-type passive transfer reactions and by an indirect hemagglutination technique developed for these studies. The occurrence of type I hypersensitivity to this topical antibiotic is rare. It is speculated that pharmaceuticals normally having a low sensitizing potential might demonstrate increased reaginic immunogenicity in a spontaneously or iatrogenically T cell-depleted patient.
J D Lakin, and
W R Grace, and
K W Sell
August 1986,
British journal of haematology,
J D Lakin, and
W R Grace, and
K W Sell
August 1975,
Annals of internal medicine,
J D Lakin, and
W R Grace, and
K W Sell
October 1987,
Blood,
J D Lakin, and
W R Grace, and
K W Sell
June 1987,
Clinical and experimental immunology,
J D Lakin, and
W R Grace, and
K W Sell
April 1996,
Bone marrow transplantation,
J D Lakin, and
W R Grace, and
K W Sell
March 1994,
Journal of clinical immunology,
J D Lakin, and
W R Grace, and
K W Sell
January 1987,
Acta haematologica,
J D Lakin, and
W R Grace, and
K W Sell
November 1988,
Bone marrow transplantation,
J D Lakin, and
W R Grace, and
K W Sell
November 1987,
Blood,
J D Lakin, and
W R Grace, and
K W Sell
February 1990,
Blood,
