OBJECTIVE To study the risk factors for renal failure during the early period after standard orthotopic liver transplantation (SOLT) without veno venous bypass (VVBP). METHODS Clinical data of 100 cases in whom SOLT without VVBP was performed were reviewed. They were divided into two groups according to serum creatine level just after operation. In both groups, Child-Turcotte-Pugh (CTP) score, model for end stage liver disease (MELD) score, acute physiology and chronic health evaluation III (APACHE III) scores, 8 laboratory variables before operation and 10 variables during the operation were analyzed, in order to screen presumable risk factors. RESULTS With univariate analysis, it was found that there was significant difference between the two groups in the following variables: CTP score, MELD score, APACHE III score, duration of operation and anhepatic phase, amount of blood loss, lowest mean artery pressure, and duration of low blood pressure. With logistic regression analysis, it was revealed that CTP score, volume of blood loss, and duration of anhepatic phase and low blood pressure were risk factors for development of acute renal failure. CONCLUSIONS CTP score, volume of blood loss, duration of anhepatic phase and low blood pressure are risk factors for development of acute renal failure after SOLT without VVBP.