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Plasma concentrations of vasoactive intestinal polypeptide in severely burned patients: influence of enteral nutrition. 1986

M Vaubourdolle, and M Salvucci, and L Cynober, and N Lioret, and R Saizy, and J Giboudeau
Laboratoire de Biochimie A, Hôpital Saint Antoine, 184, rue du Fg Saint Antoine 75571, Paris Cedex 12, France.

Plasma vasoactive intestinal polypeptide (VIP) concentrations were measured at different days after burn injury. A significant decrease in VIP levels was observed on days 7 and 10. The influence of enteral nutrition was also investigated: a rise in plasma polypeptide levels was found at 60 min after nutrition restart on days 4 and 7 after injury. In burn patients, VIP may be involved in the multiple metabolic and hormonal responses which lead to an increase in the hypercatabolic state. The decrease in these polypeptide values should reflect enhanced utilisation or complex hormonal regulation. After enteral nutrition, the stimulation of VIP secretion disappeared after day 7 after burn injury. This phenomenon is probably mediated by a process of adaptation to continuous enteral nutrition.

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