Hemispheric lateralization of cognitive functions in children with centrotemporal spikes. 2006

N Bedoin, and V Herbillon, and I Lamoury, and P Arthaud-Garde, and K Ostrowsky, and J De Bellescize, and P Kéo Kosal, and G Damon, and Ch Rousselle
Laboratoire d'Etude des Mécanismes Cognitifs/Dynamique du Langage, UMR 5596, Université Lyon 2, 5, avenue Pierre Mendès-France, 69676, Bron Cedex, France. nathalie.bedoin@univ-lyon2.fr

We assessed the impact of unilateral epileptic foci in benign idiopathic partial epilepsy of childhood with rolandic discharges (BECT) on performance and hemispheric specialization in lateralized cognitive functions. Six children with BECT with a left-sided focus (BECT-L), 6 children with BECT with a right-sided focus (BECT-R), and 12 control children were tested in verbal, visual-spatial, and visual-attention tasks, with visual hemifield presentation. Children with BECT-R were impaired in the visual-spatial task relative to those with BECT-L, and the typical left-hemisphere (LH) advantage was not reported in the verbal task in children with BECT-L. Additionally, the classic global superiority effect was lacking in children with BECT-R, which may be due to impaired performance of the right hemisphere specialized in global (vs local)-level processing. These data argue for the deleterious effect of epileptic discharges per se on cognitive functions in the developing brain, and the decisive role of epileptic focus lateralization in specific cognitive impairments and hemispheric specialization.

UI MeSH Term Description Entries
D007839 Functional Laterality Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot. Ambidexterity,Behavioral Laterality,Handedness,Laterality of Motor Control,Mirror Writing,Laterality, Behavioral,Laterality, Functional,Mirror Writings,Motor Control Laterality,Writing, Mirror,Writings, Mirror
D008297 Male Males
D009483 Neuropsychological Tests Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury. Aphasia Tests,Cognitive Test,Cognitive Testing,Cognitive Tests,Memory for Designs Test,Neuropsychological Testing,AX-CPT,Behavioral Assessment of Dysexecutive Syndrome,CANTAB,Cambridge Neuropsychological Test Automated Battery,Clock Test,Cognitive Function Scanner,Continuous Performance Task,Controlled Oral Word Association Test,Delis-Kaplan Executive Function System,Developmental Neuropsychological Assessment,Hooper Visual Organization Test,NEPSY,Neuropsychologic Tests,Neuropsychological Test,Paced Auditory Serial Addition Test,Repeatable Battery for the Assessment of Neuropsychological Status,Rey-Osterrieth Complex Figure,Symbol Digit Modalities Test,Test of Everyday Attention,Test, Neuropsychological,Tests, Neuropsychological,Tower of London Test,Neuropsychologic Test,Test, Cognitive,Testing, Cognitive,Testing, Neuropsychological,Tests, Cognitive
D011930 Reaction Time The time from the onset of a stimulus until a response is observed. Response Latency,Response Speed,Response Time,Latency, Response,Reaction Times,Response Latencies,Response Times,Speed, Response,Speeds, Response
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D003071 Cognition Intellectual or mental process whereby an organism obtains knowledge. Cognitive Function,Cognitions,Cognitive Functions,Function, Cognitive,Functions, Cognitive
D004569 Electroencephalography Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain. EEG,Electroencephalogram,Electroencephalograms
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014794 Visual Fields The total area or space visible in a person's peripheral vision with the eye looking straightforward. Field, Visual,Fields, Visual,Visual Field
D019305 Epilepsy, Rolandic An autosomal dominant inherited partial epilepsy syndrome with onset between age 3 and 13 years. Seizures are characterized by PARESTHESIA and tonic or clonic activity of the lower face associated with drooling and DYSARTHRIA. In most cases, affected children are neurologically and developmentally normal. (From Epilepsia 1998 39;Suppl 4:S32-S41) Benign Childhood Epilepsy With Centro-Temporal Spikes,Benign Epilepsy With Centrotemporal Spikes,Benign Rolandic Epilepsy of Childhood,Epilepsy, Centrotemporal,Rolands Epilepsy,Sylvian Epilepsy,BCECTS,BECTS,Benign Epilepsy Of Childhood With Centrotemporal Spikes,Benign Rolandic Epilepsy,Centralopathic Epilepsy,Centrotemporal Epilepsy,Temporal-Central Focal Epilepsy,Benign Childhood Epilepsy With Centro Temporal Spikes,Centralopathic Epilepsies,Centrotemporal Epilepsies,Epilepsies, Centralopathic,Epilepsies, Centrotemporal,Epilepsies, Rolandic,Epilepsies, Temporal-Central Focal,Epilepsy, Benign Rolandic,Epilepsy, Centralopathic,Epilepsy, Rolands,Epilepsy, Sylvian,Epilepsy, Temporal-Central Focal,Focal Epilepsies, Temporal-Central,Focal Epilepsy, Temporal-Central,Rolandic Epilepsies,Rolandic Epilepsy,Rolandic Epilepsy, Benign,Temporal Central Focal Epilepsy,Temporal-Central Focal Epilepsies

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