The purpose of this study was to explore self-care management strategies and risk factors for depressive symptoms among elderly residents of nursing homes in Taiwan. Stratified random sampling was used to recruit participants (n = 220). In these elderly nursing home residents, the prevalence of depressive tendency was 55.0%. Although only 42% of participants used self-care strategies to manage depressive symptoms, the most frequently used strategy was "take a walk." Self-learning was the main information source for self-care strategies. Logistic regression analysis indicated that satisfaction with living situation and perceived health status significantly predicted depressive symptoms. Since elders tended to engage in activities and interact with others to manage their depressive symptoms, health care providers in nursing homes should consider improving access to activities and interpersonal contacts for elderly residents. Elders' awareness of strategies to self-manage depressive symptoms also needs to be increased. The risk factors for depressive symptoms may be addressed by providing a pleasant and comfortable living environment, discouraging poor perceived health status, and promoting the health of elderly residents of nursing homes in Taiwan.