Biomaterial Database

UVB radiation and DNFB skin painting induce suppressor cells universally in mice. 1990

M J Glass, and P R Bergstresser, and R E Tigelaar, and J W Streilein

Department of Dermatology, University of Texas Health Science Center, Dallas/Southwestern Medical School 75235.

Ultraviolet radiation (UVR)3 from within the spectrum B (UVB) has the capacity to distort the induction of contact hypersensitivity (CH) in murine skin. A damaging effect of UVB on epidermal Langerhans cells (LC) appears to be universal in all genetically defined strains of mice tested. However, while UVB impairs the induction of CH in some strains of mice, it has no apparent effect on CH in others. Thus, a disparity exists between the effects of UVB on LC and on CH. This is a paradox because LC are generally regarded to serve as the antigen-presenting cells of the skin, placing them at the earliest stages of induction of CH. One possible explanation for this paradox has been that UVB-susceptible strains of mice may generate hapten-specific suppressor T cells, whereas their UVB-resistant counterparts may not, when their skin is treated with UVR and painted with haptens such as dinitrofluorobenzene (DNFB). This possibility was excluded by examining the capacity of UVR and hapten to generate suppressor T cells in several different inbred strains of mice. The results indicate that the induction of hapten-specific afferent T suppressor cells is a universal sequela to treatment of mice with UVB and hapten, irrespective of whether the mice display the phenotype of vigorous CH or not. Thus, the genetic basis of UVB-resistance does not reside in the ability of UVR to induce suppressor T cells. Rather, attention should now be focused on its ability to interrupt induction of effector mechanisms.

UI	MeSH Term	Description	Entries
D008221	Lymphoid Tissue	Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of LYMPHOCYTES can form, mature and multiply. The lymphoid tissues are connected by a network of LYMPHATIC VESSELS.	Lymphatic Tissue,Lymphatic Tissues,Lymphoid Tissues,Tissue, Lymphatic,Tissue, Lymphoid,Tissues, Lymphatic,Tissues, Lymphoid
D008815	Mice, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.	Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D009578	Nitrobenzenes	BENZENE derivatives carrying nitro group substituents.
D011836	Radiation Tolerance	The ability of some cells or tissues to survive lethal doses of IONIZING RADIATION. Tolerance depends on the species, cell type, and physical and chemical variables, including RADIATION-PROTECTIVE AGENTS and RADIATION-SENSITIZING AGENTS.	Radiation Sensitivity,Radiosensitivity,Sensitivity, Radiation,Tolerance, Radiation,Radiation Sensitivities,Radiation Tolerances,Radiosensitivities,Sensitivities, Radiation,Tolerances, Radiation
D003877	Dermatitis, Contact	A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.	Contact Dermatitis,Dermatitis Venenata,Eczema, Contact,Hypersensitivity, Contact,Sensitivity, Contact,Contact Dermatitides,Contact Eczema,Contact Hypersensitivities,Contact Hypersensitivity,Contact Sensitivities,Contact Sensitivity,Dermatitides, Contact,Hypersensitivities, Contact,Sensitivities, Contact
D004139	Dinitrofluorobenzene	Irritants and reagents for labeling terminal amino acid groups.	DNFB,Fluorodinitrobenzene,1-Fluoro-2,4-dinitrobenzene,1 Fluoro 2,4 dinitrobenzene
D005260	Female		Females
D000287	Administration, Topical	The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.	Drug Administration, Topical,Administration, Topical Drug,Topical Administration,Topical Drug Administration,Administrations, Topical,Administrations, Topical Drug,Drug Administrations, Topical,Topical Administrations,Topical Drug Administrations
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000939	Epitopes	Sites on an antigen that interact with specific antibodies.	Antigenic Determinant,Antigenic Determinants,Antigenic Specificity,Epitope,Determinant, Antigenic,Determinants, Antigenic,Specificity, Antigenic